82 articles for thisTarget
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Article Title
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Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
Icahn School of Medicine At Mount Sinai
Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.
Cellzome
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Ambit Biosciences
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
Pfizer
Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors.
Shanghai Jiao Tong University
Novel Diaminopyrimidine Carboxamides as HPK1 Inhibitors for Treating Cancer.
Smith, Gambrell & Russell
Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Emd Serono Research & Development Institute
Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors.
Shanghai Institute of Materia Medica
Development of a series of quinazoline-2,5-diamine derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors.
Shanghai Institute of Materia Medica
Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy.
Central China Normal University
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia.
Hefei Institutes of Physical Science
Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Incyte Research Institute
Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective.
China Pharmaceutical University
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Genentech
Novel Isoindolone Compounds as HPK1 Inhibitors for Treating Cancer.
Smith, Gambrell & Russell
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
Merck
Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1.
Bristol Myers Squibb
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.
Biogen
ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.
University of Florida
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application.
Takeda Pharmaceutical
PYRROLO[1,2-b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
Suven Life Sciences
4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS
Bayer Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.
Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.
Ontario Institute for Cancer Research
PYRIDO[4,3-b]INDOLE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
Ventus Therapeutics U.S.
HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
Chengdu Cynogen Bio-Pharmaceutical Technology
Substituted pyrazolo[4,3-d]pyrimidines and imidazo[5,1 -f][1,2,4]triazines as androgen receptor and phosphodiesterase dual inhibitors
Ildong Pharmaceutical
TRIAZOLE DERIVATIVES AND THEIR USE AS TANKYRASE INHIBITORS
Oslo Universitetssykehus
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma
Amide compound having bet proteolysis-inducing action and medicinal application thereof
Mitsubishi Tanabe Pharma
Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators
Janssen Pharmaceutica
Pharmaceutical compounds for treatment of medical disorders
Achillion Pharmaceuticals
1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
University of Illinois
Substituted dihydroimidazopyridinediones as MKNK1 and MKNK2 inhibitors
Bayer Pharma Aktiengesellschaft
Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
Oblique Therapeutics
Cyanopyrrolidine derivatives with activity as inhibitors of USP30
Mission Therapeutics
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
Boehringer Ingelheim International
Non-aromatic difluoro analogues of resorcylic acid lactones
University of North Carolina At Greensboro
2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
Alpha-(3,5-dimethoxybenzylidene)-alpha′-hydrocarbyl methylene cyclic ketone and preparation method thereof
Pharmaxyn Laboratories