Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50023732
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 573266BDBM573266(US11453683, Example 109 | US20230279025, Example 1...)
Affinity DataIC50: 2nMAssay Description:Binding affinity to recombinant human His10-tagged SOS1 (564 to 1049 residues) assessed as inhibition of GST-tagged human KRAS G12C mutant (1 to 169 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559636BDBM50559636(CHEMBL4760447)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667438BDBM50667438(CHEMBL6192917)
Affinity DataIC50: 3.40nMAssay Description:Binding affinity to recombinant human His10-tagged SOS1 (564 to 1049 residues) assessed as inhibition of GST-tagged human KRAS G12C mutant (1 to 169 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667440BDBM50667440(CHEMBL6192932)
Affinity DataIC50: 10nMAssay Description:Binding affinity to recombinant human His10-tagged SOS1 (564 to 1049 residues) assessed as inhibition of GST-tagged human KRAS G12C mutant (1 to 169 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667439BDBM50667439(CHEMBL6188336)
Affinity DataIC50: 13nMAssay Description:Binding affinity to recombinant human His10-tagged SOS1 (564 to 1049 residues) assessed as inhibition of GST-tagged human KRAS G12C mutant (1 to 169 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667438BDBM50667438(CHEMBL6192917)
Affinity DataIC50: 31nMAssay Description:Inhibition of SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in ERK phosphorylation measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559646BDBM50559646(CHEMBL4745494)
Affinity DataIC50: 34nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559641BDBM50559641(CHEMBL4798451)
Affinity DataIC50: 40nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601084BDBM50601084(CHEMBL5192659 | US11702418, Example 12-10)
Affinity DataIC50: 43nMAssay Description:Inhibition of SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in ERK phosphorylation measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581659BDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 44nMAssay Description:Inhibition of SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in ERK phosphorylation measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667439BDBM50667439(CHEMBL6188336)
Affinity DataIC50: 58nMAssay Description:Inhibition of SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in ERK phosphorylation measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667440BDBM50667440(CHEMBL6192932)
Affinity DataIC50: 90nMAssay Description:Inhibition of SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in ERK phosphorylation measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 573583BDBM573583(US11453683, Example 181 | US20230279025, Example 1...)
Affinity DataIC50: 2.96E+3nMAssay Description:Binding affinity to recombinant human His10-tagged SOS1 (564 to 1049 residues) assessed as inhibition of GST-tagged human KRAS G12C mutant (1 to 169 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed