50 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.
East China University of Science and Technology
Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation.
University of Mansoura
Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase.
Janssen Research and Development
Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase.
Peking University
Azabenzthiazole inhibitors of leukotriene A4 hydrolase.
Janssen Research and Development
Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors.
University of Upper Alsace
Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.
Pfizer
Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.
Searle Research and Development
5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Amira Pharmaceuticals
Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase.
Peking University
Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors.
Gyeongsang National University (Gnu)
Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13.
Merck Sharpe and Dohme
Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.
Decode Chemistry
Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
Decode Chemistry
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
Decode Biostructures
Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus.
Searle Research and Development
Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching.
Peking University
Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors.
Santen Pharmaceutical
Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.
Peking University
Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.
Santen Pharmaceutical
Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors.
Berlex Biosciences
Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase.
Berlex Biosciences
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
Johann Wolfgang Goethe University
Synthesis and Evaluation of diaryl ether modulators of the leukotriene A4 hydrolase aminopeptidase activity.
George Mason University
Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor.
Novartis Pharma
ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights.
University of Lille
Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.
Novartis Pharma
Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.
Pfizer
Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.
Pharmacia
Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase.
Goethe-University
Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA
Goethe University Frankfurt
Recent developments in the synthesis and applications of phosphinic peptide analogs.
Wroclaw University of Technology
Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.
Scripps Research Institute
NEUROACTIVE STEROIDS SUBSTITUTED IN POSITION 10 WITH A CYCLIC GROUP FOR USE IN THE TREATMENT OF CNS DISORDERS
Sage Therapeutics
SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES
THE SCRIPPS RESEARCH INSTITUTE
Substituted amino six-membered saturated heteroalicycles as long-acting DPP-IV inhibitors
Centaurus Biopharma
Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.
Fayoum University
Conformationally restricted urea inhibitors of soluble epoxide hydrolase
University of California