82 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Structure-guided design of new indoles as negative allosteric modulators (NAMs) of N-methyl-D-aspartate receptor (NMDAR) containing GluN2B subunit.
Farmaceutiche Ed Ambientali (Chibiofaram) Universit£
Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Structure-activity relationships of N-substituted 4-(trifluoromethoxy)benzamidines with affinity for GluN2B-containing NMDA receptors.
The University of Sydney
Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors.
University of Messina
From NMDA receptor antagonists to discovery of selectives2 receptor ligands.
University of Messina
Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.
Emory University
Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.
University of Messina
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.
University of Messina
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.
Istituto Italiano Di Tecnologia
Synthesis and in vitro characterization of trans- and cis-[(18)F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-D-aspartate receptor.
Institute of Biomedical Imaging (I2Bm)
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.
Glaxosmithkline
Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors.
University of Strasburg
Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors.
University of Messina
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.
Astrazeneca Pharmaceuticals
Synthesis and biological evaluation of radio-iodinated benzimidazoles as SPECT imaging agents for NR2B subtype of NMDA receptor.
Hamamatsu University School of Medicine
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.
Emory University
Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists.
Merck Research Laboratories
Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists.
Università
Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.
University of Utah
Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity.
Pfizer
Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation.
Pfizer
Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain.
Pfizer
Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists.
Merck Research Laboratories
Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.
University Munster
Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides.
Gedeon Richter
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
Merck Research Laboratories
Identification and in silicon binding study of a novel NR2B selective NMDAR antagonist.
Shenyang Pharmaceutical University
Recent developments on synthesis and biological activities of γ-carboline.
Northwest A&F University
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.
Takeda Pharmaceutical
β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy.
Univ. Grenoble Alpes
Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.
Gedeon Richter
Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.
Yeditepe University
1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.
F. Hoffmann-La Roche
Orally efficacious NR2B-selective NMDA receptor antagonists.
Merck Research Laboratories
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.
Merck Research Laboratories
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.
Westf£Lische Wilhelms-Universit£T M£Nster
Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.
F. Hoffmann-La Roche
Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.
University of Trieste
Thiophene bioisosteres of GluN2B selective NMDA receptor antagonists: Synthesis and pharmacological evaluation of [7]annuleno[b]thiophen-6-amines.
Westf£Lische Wilhelms-Universit£T M£Nster
Parallel synthesis of a series of subtype-selective NMDA receptor antagonists.
Parke-Davis Pharmaceutical Research
Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Modification of the 4-phenylbutyl side chain of potent 3-benzazepine-based GluN2B receptor antagonists.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
(3R,4S)-3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: a conformationally restricted analogue of the NR2B subtype-selective NMDA antagonist (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)- 1-propanol.
Pfizer
Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization.
Shionogi
Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.
University of Bristol
Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position.
University Munster
Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation.
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.
Universit£T M£Nster
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
Bristol-Myers Squibb Research and Development
Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach.
Shionogi
DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
Arena Pharmaceuticals
Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
Bayer Aktiengesellschaft
2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
Ideaya Bioscience
Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
Chia Tai Tianqing Pharmaceutical Group
Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators
Janssen Pharmaceutica
Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
Forma Therapeutics
Isoxazole compounds as inhibitors of heat shock proteins
The Institute of Cancer Research
The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.
East China University of Science and Technology
5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use
Cancer Research Technology
2-amino 6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
H. Lundbeck
Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives.
University of Karachi
Derivatives of propargylamine having neuroprotective capacity for the treatment of Alzheimer's and Parkinson's diseases
Consejo Superior De Investigaciones Cientificas
Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding.
Academia Sinica