BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

24 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.EBI
Leiden University
Discovery and characterization of an inhibitor of glucosylceramide synthase.EBI
Exelixis
Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.EBI
TBA
Discovery of a new class of glucosylceramide synthase inhibitors.EBI
Exelixis
Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated IminosugarsEBI
TBA
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.EBI
Leiden University
 
Synthesis and biological evaluation of four stereoisomers of PDMP-analogue, N-(2-decylamino-3-hydroxy-3-phenylprop-1-yl)-β-valienamine, and related compoundsEBI
TBA
Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.EBI
University of Oxford
Novel Fused Pyrazole Amide Analogs as Glucosylceramide Synthase Inhibitors for Treating Lysosomal Storage Diseases, Neurodegenerative Diseases, Cystic Diseases, and Cancer.EBI
Smith, Gambrell & Russell
Fused Pyrazole Urea Analogs as Glucosylceramide Synthase Inhibitors for Treating Diseases.EBI
Smith, Gambrell & Russell
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.EBI
Merck
Amphiphilic glycoconjugates as potential anti-cancer chemotherapeutics.EBI
Emory University
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.EBI
Merck
Photoredox-based late-stage functionalization in SAR study for in vivo potent glucosylceramide synthase inhibitor.EBI
Takeda Pharmaceutical
Modified Benzofuran-carboxamide Compounds as Glucosylceramide Synthase Inhibitors for Treating Diseases.EBI
Smith, Gambrell & Russell
Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore.EBI
Takeda Pharmaceutical
New PDMP analogues inhibit process outgrowth in an insect cell line.EBI
University of Arizona
PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOFBDB
Calico Life Sciences
Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereofBDB
Cambridge Enterprise
HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOFBDB
Hutchison Medipharma
Substituted lactams showing serotonin 5-HT receptor activityBDB
Sumitomo Pharma
Heterocyclic compounds as FGFR inhibitorsBDB
Guangzhou Innocare Pharma Tech
Design, synthesis and anticholinesterase activity of some new a-aminobisphosphonates.BDB
Tarbiat Modares University
Synthesis, methods of using, and compositions of cycloalkylmethylaminesBDB
Reviva Pharmaceuticals