58 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomalß-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.
Orleans University
Strategy for designing selectivea-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.
University of Toyama
Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.
University of Seville
Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerfulß-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomalß-galactosidase.
Graz University of Technology
Illuminating the binding interactions of galactonoamidines during the inhibition ofß-galactosidase (E. coli).
University of Arkansas
Quaternary Indolizidine and Indolizidone Iminosugars as Potential Immunostimulating and Glycosidase Inhibitory Agents: Synthesis, Conformational Analysis, Biological Activity, and Molecular Docking Study.
Savitribai Phule Pune University (Formerly University of Pune)
Synthesis and biological evaluation of N-(2-fluorophenyl)-2ß-deoxyfuconojirimycin acetamide as a potent inhibitor fora-l-fucosidases.
University of Toyama
Skeletal rearrangement of seven-membered iminosugars: synthesis of (-)-adenophorine, (-)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors.
University of Poitiers
Pharmacological chaperones as therapeutics for lysosomal storage diseases.
Amicus Therapeutics
Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles.
Academy of Sciences of The Czech Republic
a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia.
University of Toyama
Isolation of glycosidase-inhibiting hyacinthacines and related alkaloids from Scilla socialis.
University of Toyama
Biological properties of D- and L-1-deoxyazasugars.
Toyama Medical and Pharmaceutical University
Synthesis of 5a-carba-hexopyranoses and hexopyranosylamines, as well as 5a,5a'-dicarbadisaccharides, from 3,8-dioxatricyclo[4.2.1.0(2,4)]nonan-9-ol: glycosidase inhibitory activity of N-substituted 5a-carba-beta-gluco- and beta-galactopyranosylamines, and derivatives thereof.
Keio University
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.
Northwestern University
Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.
Hokuriku University
Convenient synthesis and evaluation of enzyme inhibitory activity of several N-alkyl-, N-phenylalkyl, and cyclic isourea derivatives of 5a-carba-alpha-DL-fucopyranosylamine.
Keio University
New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives.
Universidad De Sevilla
Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.
Section De Chimie De L'Universit£
The Interaction of Anhydroalditols with Sweet-Almond -glucosidase and Escherichia coli -galactosidase: implications for the design of potent glycosidase inhibitors
TBA
Concise synthesis of (+)-conduritol F and inositol analogues from naturally available (+)-proto-quercitol and their glucosidase inhibitory activity.
Chulalongkorn University
Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes.
Umr Cnrs 7201
Transformation of quercitols into 4-methylenecyclohex-5-ene-1,2,3-triol derivatives, precursors for the chemical chaperones N-octyl-4-epi-ß-valienamine (NOEV) and N-octyl-ß-valienamine (NOV).
Hokko Chemical Industry
A fluorescent probe for GM1 gangliosidosis relatedß-galactosidase: N-(dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-D-galactitol.
Industrial Research
Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes.
University of Reading
Docking and SAR studies of D- and L-isofagomine isomers as humanß-glucocerebrosidase inhibitors.
University of Toyama
New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.
Spanish National Research Council (Consejo Superior De Investigaciones Cienti£?Ficas)
Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars
TBA
Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging.
Katholieke Universiteit Leuven
1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors.
Technische UniversitäT Graz
Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana.
Hokuriku University
New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica.
Hokuriku University
Flexible synthesis and biological evaluation of novel 5-deoxyadenophorine analogues.
Université
Fluorescent glycosidase inhibiting 1,5-dideoxy-1,5-iminoalditols.
Technische UniversitäT Graz
Synthesis and glycosidase inhibitory activity of some N-substituted 6-deoxy-5a-carba-beta-DL- and L-galactopyranosylamines.
Keio University
Synthesis of [(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-5-methylfuran-4-carboxylic acid derivatives: new leads as selective beta-galactosidase inhibitors.
Universidad De Sevilla
Revised structure of a homonojirimycin isomer from Aglaonema treubii: first example of a naturally occurring alpha-homoallonojirimycin.
Institut De Chimie Organique Et Analytique (I.C.O.A.)
Synthesis of alpha-C(1-->3)-mannopyranoside of N-acetylgalactosamine, a new beta-galactosidase inhibitor.
Institut De Chimie Organique De L'Université
Pharmaceutical significance of azepane based motifs for drug discovery: A critical review.
Wuhan Institute of Technology
Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative.
Institut De Chimie Organique De L'Université
Resveratrol-Related Polymethoxystilbene Glycosides: Synthesis, Antiproliferative Activity, and Glycosidase Inhibition.
University of Catania
Structure-activity relationship of highly potent galactonoamidine inhibitors toward β-galactosidase (Aspergillus oryzae).
University of Arkansas
Synthesis of pentopyranosyl-containing thiodisaccharides. Inhibitory activity against beta-glycosidases.
Universidad De Buenos Aires
4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations.
Orleans University
Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors.
University of Seville
Tuning of β-glucosidase and α-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules.
University of Seville
Picomolar inhibition ofβ-galactosidase (bovine liver) attributed to loop closure.
University of Arkansas
N-Butyl-l-deoxynojirimycin (l-NBDNJ): Synthesis of an Allosteric Enhancer ofα-Glucosidase Activity for the Treatment of Pompe Disease.
University of Naples Federico II
Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.
Cns Biological Research
Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.
Eli Lilly
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors.
Enscmu