30 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-ß-lactamases and arginases.
The University of Queensland
Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction.
Institutes For Pharmaceutical Discovery
2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.
Institutes For Pharmaceutical Discovery
Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.
Institutes For Pharmaceutical Discovery
N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.
Christian-Albrechts-University of Kiel
Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.
Drexel University
Binding ofa,a-disubstituted amino acids to arginase suggests new avenues for inhibitor design.
Drexel University
2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.
University of Pennsylvania
Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.
Flinders University
Recent advances in small molecule based cancer immunotherapy.
Southern Medical University
Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods.
Merck
If small molecules immunotherapy comes, can the prime be far behind?
Zhejiang University
Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores.
Sichuan University
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
Merck
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Quantitative Biosciences
Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors.
Univ. Bourgogne Franche-Comt�
Novel Arginase Inhibitors for Treating Cancer and Respiratory Inflammatory Diseases.
Smith, Gambrell & Russell
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
Merck
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.
University of Louvain
Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors.
Oncoarendi Therapeutics
Purine derivatives and the use thereof as medicament
Boehringer Ingelheim International