28 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands fora-Synuclein Fibrils.
Washington University
Structure-Activity Relationships of Cyano-substituted Indole Derivatives as Ligands for α-Synuclein Aggregates.
Beijing Normal University
Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.
Zhengzhou University
Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates.
Sun Yat-Sen University
Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and in vitro disaggregation activity against α-synuclein oligomers and fibrils.
Zhengzhou University
4-Arylidene curcumin derivatives in vitro inhibit α-Synuclein aggregation and disaggregate the preformed fibril.
Zhengzhou University
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
Sun Yat-Sen University
Small molecule-based fluorescent probes for the detection of α-Synuclein aggregation states.
Csir-Indian Institute of Chemical Technology (CSIR-IICT)
Evolution in non-peptide α-helix mimetics on the road to effective protein-protein interaction modulators.
IQM-CSIC
Bioactive Aurones, Indanones, and Other Hemiindigoid Scaffolds: Medicinal Chemistry and Photopharmacology Perspectives.
Universite Grenoble Alpes
Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects.
German University In Cairo
Hybrids of polyphenolic acids and xanthone, the potential preventive and therapeutic effects on PD: Design, synthesis, in vitro anti-aggregation of α-synuclein, and disaggregation against the existed α-synuclein oligomer and fibril.
Zhengzhou University
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.
Fudan University
Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation.
University of Catania
Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for α-synuclein fibrils by SPR evaluation system.
Fudan University
Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro α-synuclein aggregation.
Zhengzhou University
Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation.
Zhengzhou University
Novel Bis-heteroaryl Derivatives To Modulate Protein Aggregation for the Treatment of Neurodegenerative Diseases.
Drexel University
A routinely used protein staining dye acts as an inhibitor of wild type and mutant alpha-synuclein aggregation and modulator of neurotoxicity.
National Institute of Immunology
Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases
Regents of The University of Colorado, A Body Corporate
Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Galapagos
Imidazo isoindole derivative, preparation method therefor and medical use thereof
Jiangsu Hengrui Medicine
Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1a prolyl hydroxylases-1, -2, and -3 with altered selectivity.
Amgen