The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.5M data for 728K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

10 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.EBI
University of Cambridge
Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer.EBI
China Pharmaceutical University
GPX4 allosteric activators inhibit ferroptosis and exert myocardial protection in doxorubicin-induced myocardial injury mouse model.EBI
Peking University
Research progress on GPX4 targeted compounds.EBI
Peking University
Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors.EBI
China Pharmaceutical University
Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer.EBI
China Pharmaceutical University
Dual degradation mechanism of GPX4 degrader in induction of ferroptosis exerting anti-resistant tumor effect.EBI
Peking University
Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells.EBI
Peking University
Structure-activity relationships of GPX4 inhibitor warheads.EBI
Institute of Mit and Harvard
Allosteric Modulator Discovery: From Serendipity to Structure-Based Design.EBI
Shanghai Jiao-Tong University School of Medicine