31 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT
University of Montreal
Urotensin II((4-11)) Azasulfuryl Peptides: Synthesis and Biological Activity.
University of Montreal
De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one¿-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo.
University of Montreal
Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists.
University of Montreal
Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists.
University of Montreal
Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one.
University of Montreal
Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a.
University of Montreal
Synthesis of stable and selective inhibitors of human galectins-1 and -3.
University of Montreal
Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.
University of Montreal
Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.
University of Montreal
Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure.
University of Montreal
The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity.
University of Montreal
Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.
University of Montreal
Synthesis of S-alkyl L-homocysteine analogues of glutathione and their kinetic studies with gamma-glutamyl transpeptidase.
University of Montreal
Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones.
University of Montreal
Design and synthesis of a new sialyl Lewis X mimetic: how selective are the selectin receptors?
University of Montreal
Exploring the chiral space within the active site of alpha-thrombin with a constrained mimic of D-Phe-Pro-Arg--design, synthesis, inhibitory activity, and X-ray structure of an enzyme-inhibitor complex.
University of Montreal
Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.
University of Montreal
Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.
University of Montreal
Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity.
University of Montreal
Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.
University of Montreal
From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs.
University of Montreal
Sialyl LewisX glycomimetics bearing an extended anionic chain targeting E- and P- selectin binding sites.
University of Montreal
Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25.
University of Montreal
Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics.
University of Montreal
Synthesis of NVS-BPTF-1 and evaluation of its biological activity.
University of Montreal
Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.
University of Montreal
Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics.
University of Montreal