75 articles for thisTarget
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Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.
Purdue Pharma
1,3-Dihydro-2,1,3-benzothiadiazol-2,2-diones and 3,4-dihydro-1H-2,1,3-benzothidiazin-2,2-diones as ligands for the NOP receptor.
Purdue Pharma
Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints.
Purdue Pharma
Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists.
Purdue Pharma
Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor.
Purdue Pharma
4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists.
Purdue Pharma
Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor.
Purdue Pharma
Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof
Beijing Innocare Pharma Tech
Vasopressin receptor antagonists and products and methods related thereto
Blackthorn Therapeutics
A screening assay for neuraminidase inhibitors using neuraminidases N1 and N3 from a baculovirus expression system.
Chulalongkorn University
Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
University of Cambridge
Rational design and synthesis of dihydropyrimidine based dual binding site acetylcholinesterase inhibitors.
Hazara University
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.
Genentech
Rational design, synthesis, anti-HIV-1 RT and antimicrobial activity of novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one derivatives.
Birla Institute of Technology
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.
Harvard Medical School
Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments
Sanofi
Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy
Pantarhei Bioscience
1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D.
University of Massachusetts Boston
Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a.
North Dakota State University
Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1.
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia
Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation.
French Alternative Energies and Atomic Energy Commission
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
I.G.B.M.C.
Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells.
University of Texas At Austin
Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.
Case Western Reserve University
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Case Western Reserve University
SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist.
Schering-Plough Research Institute
Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.
The Royal Danish School of Pharmacy
Synthetic modification of prostaglandin f(2alpha) indicates different structural determinants for binding to the prostaglandin F receptor versus the prostaglandin transporter.
Albert Einstein College of Medicine
Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors.
Cocensys
Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties.
Universidad De Sevilla
A new series of S-adenosyl-L-methionine synthetase inhibitors.
Laboratoire De Chimie Bioorganique
Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.
Glaxo Wellcome Research and Development
I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor.
Neurogen
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.
Massachusetts General Hospital
The binding of [3H]nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats.
University of Arizona
The binding of [3H]-prostacyclin to membranes of a neuronal somatic hybrid.
Royal Postgraduate Medical School
(-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.
Johns Hopkins University