BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 708K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

26 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors.EBI
Merck Serono
Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.EBI
Merck Serono
Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I.EBI
Merck Serono
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.EBI
Merck Serono
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.EBI
Merck Serono
Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.EBI
Merck Serono
Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors.EBI
Merck Serono
Discovery of a novel series of CXCR3 antagonists.EBI
Merck Serono
Discovery of a novel series of potent S1P1 agonists.EBI
Merck Serono
Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.EBI
Merck Serono
Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists.EBI
Merck Serono
Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.EBI
Merck Serono
Non-nucleoside reverse transcriptase inhibitorsBDB
Merck Sharp & Dohme
Small molecule inhibitors of RGS proteinsBDB
University of Michigan
[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.BDB
Merck Research Laboratories
SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity.BDB
Smithkline Beecham Pharmaceuticals
D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs.BDB
Case Western Reserve University
Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line.BDB
University of Nebraska
Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.BDB
National Institutes of Diabetes and Digestive and Kidney Diseases
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2.BDB
Stanford University
The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.BDB
Merck Research Laboratories