The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 748K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

75 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS, COMBINATIONS AND USES RELATED THERETOBDB
Emory University
2,3-DIHYDROBENZO[B][1,4]DIOXIN-6-YL CONTAINING COMPOUNDS USEFUL AS IMMUNOMODULATORSBDB
Bristol-Myers Squibb
SPIROCYCLIC MDM2 MODULATOR AND USES THEREOFBDB
Newave Pharmaceutical
COMPOUNDS AND METHODS FOR TREATING CORONA VIRUSESBDB
Clear Creek Bio
PYRIDO[4,3-b]INDOLE DERIVATIVES AND THEIR USE AS PHARMACEUTICALSBDB
Ventus Therapeutics U.S.
COMBINATION OF AN ALPHA2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEABDB
Bayer Aktiengesellschaft
Compound having KDM5 inhibitory activity and pharmaceutical use thereofBDB
Ono Pharmaceutical
Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereofBDB
Ocuterra Therapeutics
JAK1 pathway inhibitors for the treatment of gastrointestinal diseaseBDB
Incyte
MAP4K1 inhibitorsBDB
Blueprint Medicines
JAK inhibitor and use thereofBDB
Zhuhai United Laboratories
Pyrimidine derivative having effect of inhibiting cancer cell growth and pharmaceutical composition containing sameBDB
Oncobix
Macrocyclic immunomodulatorsBDB
Chemocentryx
Naphthyridines as inhibitors of HPK1BDB
Genentech
Heteroaryl inhibitors of PAD4BDB
Padlock Therapeutics
Cycloalkyl substituted triazole compounds as agonists of the APJ receptorBDB
Amgen
Pyrazolopyrimidine compounds and uses thereofBDB
Incyte
Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitorsBDB
Pfizer
Biaryltriazole inhibitors of macrophage migration inhibitory factorBDB
Yale University
Substituted aminoquinazoline compounds as A2A antagonistBDB
Merck Sharp & Dohme
ASK1 inhibitor and preparation method and use thereofBDB
Fuijan Cosunter Pharmaceutical
Nitrogen-containing heteroaryl compound and pharmaceutical use thereofBDB
Japan Tobacco
Mutant IDH1 inhibitorsBDB
Eli Lilly
Heterocyclic derivatives and their use in the treatment of neurological disordersBDB
Novartis
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2BDB
Merck Sharp & Dohme
Triazole DAGLα inhibitorsBDB
The Scripps Research Institute
KDM1A inhibitors for the treatment of diseaseBDB
Imago Biosciences
Substituted benzamidesBDB
Hoffmann-La Roche
Pharmaceutical composition comprising pyridone derivativesBDB
Sk Biopharmaceuticals
Pyrazolopyridine compounds and uses thereofBDB
Incyte
Compounds as inhibitors of DNA methyltransferasesBDB
FundaciÓN Para La InvestigaciÓN MÉDica Aplicada
Fused pyrimidine compound, and preparation method, intermediate, composition, and uses thereofBDB
Shanghai Yingli Pharmaceutical
Substituted benzoxazoles and methods of use thereofBDB
Genentech
Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredientBDB
Ahn-Gook Pharmaceutical
Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereofBDB
Sanofi
Interaction of superoxide dismutase with the glycine zipper regions of ß-amyloid peptides: is there an implication towards Alzheimer's disease and oxidative stress?BDB
Rhodes University
Autotaxin inhibitorsBDB
Novartis
Inhibition of acetylpolyamine and spermine oxidases by the polyamine analogue chlorhexidine.BDB
University Roma Tre
Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules.BDB
Kirklareli University
Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations.BDB
City University of New York Hunter College
New antihyperglycemic, alpha-glucosidase inhibitory, and cytotoxic derivatives of benzimidazoles.BDB
Indian Institute of Chemical Technology
 
Ellagitannin and flavonoid constituents from Agrimonia pilosa Ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activitiesBDB
Catholic University of Daegu
Kinase inhibitorsBDB
Allergan
Synthesis and preliminary biological assay of uridine glycoconjugate derivatives containing amide and/or 1,2,3-triazole linkers.BDB
Silesian University of Technology
SARMs and method of use thereofBDB
University of Tennessee Research Foundation
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitorsBDB
Novartis
Serine/threonine kinase inhibitorsBDB
Array Biopharma
Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitorsBDB
Shanghai Institute of Material Medica, Chinese Academy of Sciences
Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic-reperfusion injury via selective inhibition of MMP-9.BDB
Zhejiang Hospital
Bicyclic carboxamide inhibitors of kinasesBDB
Abbvie
Pyrimidooxazocine derivatives as mTOR-inhibitorsBDB
Sanofi
Development of hydroxylated naphthylchalcones as polyphenol oxidase inhibitors: Synthesis, biochemistry and molecular docking studies.BDB
University of Technology Sydney
Benzoxazepin compounds selective for PI3K P110 delta and methods of useBDB
Genentech
Triazolopyridine compoundsBDB
Novartis
N-benzylindole modulators of PPARGBDB
The Scripps Research Institute
Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases.BDB
University of Toronto
Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structureBDB
Vitae Pharmaceuticals
Pyrazole compounds as CRTH2 antagonistsBDB
Boehringer Ingelheim International
2,3,4,5-tetrahydro-benzo{B}{1,4}diazepine-comprising compounds of formula(III) for treating painBDB
Purde Pharma
Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1BDB
Vitae Pharmaceuticals
Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitorsBDB
Merck Sharp & Dohme
Inhibition of protein kinase C by cationic amphiphiles.BDB
Mcmaster University
Boron-based inhibitors of acyl protein thioesterases 1 and 2.BDB
Technical University of Dortmund
Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid.BDB
Gda£?Sk University of Technology
Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine.BDB
University of Miami
A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.BDB
University of North Carolina at Chapel Hill
Molecular and pharmacological characterization of muscarinic receptor subtypes in a rat parotid gland cell line: comparison with native parotid gland.BDB
Creighton University
Expression and characterization of the rat D3 dopamine receptor: pharmacologic properties and development of antibodies.BDB
University of Pennsylvania
Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex.BDB
Hoechst Pharmaceutical Research Laboratories