BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.4K Targets. Of those, 1.6M data for 748K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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22 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.EBI
Goethe University Frankfurt
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.EBI
Goethe University Frankfurt
Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.EBI
Goethe University Frankfurt
Structural Fusion of Natural and Synthetic Ligand Features Boosts RXR Agonist Potency.EBI
Goethe University Frankfurt
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.EBI
Goethe University Frankfurt
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ.EBI
Goethe University Frankfurt
The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators.EBI
Goethe University Frankfurt
Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation.EBI
Goethe University Frankfurt
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-EBI
Goethe University Frankfurt
Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.EBI
Goethe University Frankfurt
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration.EBI
Goethe University Frankfurt
Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells.EBI
Goethe University Frankfurt
Design of a Potent TLX Agonist by Rational Fragment Fusion.EBI
Goethe University Frankfurt
Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics.EBI
Goethe University Frankfurt
Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.EBI
Goethe University Frankfurt
Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor.EBI
Goethe University Frankfurt
Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.EBI
Goethe University Frankfurt
Design and Structural Optimization of Dual FXR/PPARδ Activators.EBI
Goethe University Frankfurt
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.EBI
Goethe University Frankfurt
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds.EBI
Goethe University Frankfurt
Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTAEBI
Goethe University Frankfurt
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.EBI
Goethe University Frankfurt