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Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases.
ACS Med Chem Lett 15: 6-8 (2024)
Therachem Research Medilab
Novel Pyrazolopyridine Inhibitors of Monoacylglycerol Lipase for the Treatment of Neurodegenerative Diseases and Neuroinflammation.
ACS Med Chem Lett 15: 19-20 (2024)
Arrival Discovery
Structure-Based Design and Evaluation of Reversible KRAS G13D Inhibitors.
ACS Med Chem Lett 15: 21-28 (2024)
Genentech
Discovery of Novel PDEδ Autophagic Degraders: A Case Study of Autophagy-Tethering Compound (ATTEC).
ACS Med Chem Lett 15: 29-35 (2024)
East China University of Science and Technology
Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for
ACS Med Chem Lett 15: 36-44 (2024)
Jagiellonian University
Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library.
ACS Med Chem Lett 15: 76-80 (2024)
Latvian Institute of Organic Synthesis
Chemical Catalysis Guides Structural Identification for the Major
ACS Med Chem Lett 15: 107-115 (2024)
Baylor College of Medicine
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.
ACS Med Chem Lett 15: 123-131 (2024)
Merck
Synthesis, Antiacetylcholinesterase Activity, and Molecular Dynamics Simulation of Aporphine-benzylpyridinium Conjugates.
ACS Med Chem Lett 15: 132-142 (2024)
Chulabhorn Research Institute
3-Alkynyl Carboxamides as AEP Modulators for Treating Alzheimer's Disease.
ACS Med Chem Lett 15: 159-160 (2024)
Smith, Gambrell & Russell
Novel PARP1 Inhibitors for Treating Cancer.
ACS Med Chem Lett 15: 161-162 (2024)
Smith, Gambrell & Russell
Emopamil-Binding Protein Inhibitors for Treating Multiple Sclerosis.
ACS Med Chem Lett 15: 163-164 (2024)
Smith, Gambrell & Russell
Innovative Therapeutic Strategies in TYK2-Targeted Treatments: From Cancer to Autoimmune Disorders.
ACS Med Chem Lett 15: 174-176 (2024)
Usona Institute
Novel Fused Triazole Compounds as RIPK1 Inhibitors for Treating Neurodegenerative, Autoimmune, and Inflammatory Diseases.
ACS Med Chem Lett 15: 177-178 (2024)
Smith, Gambrell & Russell
Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.
ACS Med Chem Lett 15: 181-188 (2024)
Bristol-Myers Squibb Research & Development
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
ACS Med Chem Lett 15: 189-196 (2024)
Bristol Myers Squibb
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress.
ACS Med Chem Lett 15: 205-214 (2024)
University of Illinois At Chicago
The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels.
ACS Med Chem Lett 15: 215-220 (2024)
University of Liege
Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2.
ACS Med Chem Lett 15: 250-257 (2024)
University of Florence
Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma.
ACS Med Chem Lett 15: 258-264 (2024)
Northwestern University
Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP).
ACS Med Chem Lett 15: 270-279 (2024)
Nanjing University of Chinese Medicine
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists.
ACS Med Chem Lett 15: 302-309 (2024)
Vanderbilt University
Novel Tetrahydropyrido[3,4-
ACS Med Chem Lett 15: 318-319 (2024)
Smith, Gambrell & Russell
Pyrrolidinone Derivatives as NIK Inhibitors for Treating Inflammatory and Autoimmune Diseases.
ACS Med Chem Lett 15: 322-323 (2024)
Smith, Gambrell & Russell
Novel AT2R Antagonists for Treating Chronic Pain.
ACS Med Chem Lett 15: 326-327 (2024)
Smith, Gambrell & Russell
Advancements in Predictive Medicine: NLRP3 Inflammasome Inhibitors and AI-Driven Predictive Health Analytics.
ACS Med Chem Lett 15: 331-333 (2024)
Usona Institute
Combination of Allosteric and Orthosteric EGFR Inhibitors for Treating Non-Small-Cell Lung Cancer.
ACS Med Chem Lett 15: 342-343 (2024)
Smith, Gambrell & Russell
Discovery and Characterization of Active CBP/EP300 Degraders Targeting the HAT Domain.
ACS Med Chem Lett 15: 355-361 (2024)
University of Zurich
Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
ACS Med Chem Lett 15: 381-387 (2024)
Janssen Pharmaceutical Research and Development
Synthesis and Biophysical Characterization of Fingolimod Derivatives as Cardiac Troponin Antagonists.
ACS Med Chem Lett 15: 413-417 (2024)
King'S College London
The Science and Art of Structure-Based Virtual Screening.
ACS Med Chem Lett 15: 436-440 (2024)
Astrazeneca
Novel Phosphorylpurinone Compounds for Treating Cancer.
ACS Med Chem Lett 15: 441-442 (2024)
Smith, Gambrell & Russell
Novel PCSK9 Inhibitors for Treating Cardiovascular Diseases.
ACS Med Chem Lett 15: 443-444 (2024)
Smith, Gambrell & Russell
Novel ACC Inhibitors for Treating Acne.
ACS Med Chem Lett 15: 445-446 (2024)
Smith, Gambrell & Russell
Novel Isoxazolidines as RIPK1 Inhibitors for Treating Alzheimer's Disease, Multiple Sclerosis, and Amyotrophic Lateral Sclerosis.
ACS Med Chem Lett 15: 447-448 (2024)
Smith, Gambrell & Russell
Discovery of a New Class of 1-(4-Sulfamoylbenzoyl)piperidine-4-carboxamides as Human Carbonic Anhydrase Inhibitors.
ACS Med Chem Lett 15: 470-477 (2024)
University of Cagliari
Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.
ACS Med Chem Lett 15: 478-485 (2024)
Crinetics Pharmaceuticals
Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.
ACS Med Chem Lett 15: 486-492 (2024)
Janssen Research and Development
Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.
ACS Med Chem Lett 15: 501-509 (2024)
University of Nottingham
Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability.
ACS Med Chem Lett 15: 510-517 (2024)
University of Nebraska Medical Center
Design, Synthesis, and Evaluation of 8-(
ACS Med Chem Lett 15: 518-523 (2024)
Huaqiao University
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable
ACS Med Chem Lett 15: 524-532 (2024)
Sanders Tri-Institutional Therapeutics
Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome.
ACS Med Chem Lett 15: 533-539 (2024)
Whitman College
In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833).
ACS Med Chem Lett 15: 540-545 (2024)
Pfizer
Novel Myeloperoxidase Inhibitors for Treating Multiple Diseases.
ACS Med Chem Lett 15: 569-570 (0)
Smith, Gambrell & Russell
Novel CD73 Inhibitors for Treating Cancer.
ACS Med Chem Lett 15: 571-572 (0)
Smith, Gambrell & Russell
Pyrrolidinone Derivatives as NIK Inhibitors for Treating Autoimmune and Inflammatory Diseases.
ACS Med Chem Lett 15: 581-582 (0)
Smith, Gambrell & Russell
Structural Investigations of Phthalazinone Derivatives as Allosteric Inhibitors of Human DNA Methyltransferase 3A.
ACS Med Chem Lett 15: 590-594 (0)
University of California
Discovery of Sovleplenib, a Selective Inhibitor of Syk in Clinical Development for Autoimmune Diseases and Cancers.
ACS Med Chem Lett 15: 595-601 (0)
HUTCHMED Limited
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.
ACS Med Chem Lett 15: 610-618 (0)
University of South Carolina
Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment.
ACS Med Chem Lett 15: 646-652 (0)
Cerevance Limited
Discovery of the First Potent DYRK2 Proteolysis Targeting Chimera Degraders.
ACS Med Chem Lett 15: 659-666 (0)
Sun Yat-sen University
Discovery of Novel Bicyclic Pyrazoles as Potent PIP5K1C Inhibitors.
ACS Med Chem Lett 15: 684-690 (0)
Kyorin Pharmaceutical Co., Ltd.
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
ACS Med Chem Lett 15: 714-721 (0)
Biogen
Identification of Selective Imidazopyridine CSF1R Inhibitors.
ACS Med Chem Lett 15: 722-730 (0)
Sanofi R&D
Novel 2,7-Naphthyridine Compounds as MASTL Inhibitors for Treating Cancer.
ACS Med Chem Lett 15: 748-749 (0)
Smith, Gambrell & Russell
Lysosomal Degradation of Extracellular Targets: Innovations and Implications.
ACS Med Chem Lett 15: 752-754 (0)
Usona Institute
The Inhibitors of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 (MALT-1) Protease as Potential Treatment of ABC-DLBCL and Similar Diseases.
ACS Med Chem Lett 15: 763-765 (0)
PI Health Sciences
Novel HSD17B13 Inhibitors for Treating Liver Diseases.
ACS Med Chem Lett 15: 771-772 (0)
Smith, Gambrell & Russell
Novel Heteroaryl Compounds as CD73 Inhibitors for Treating Cancer.
ACS Med Chem Lett 15: 775-776 (0)
Smith, Gambrell & Russell
Imidazopyridine Compounds as ERK5 Inhibitors for Treating Cancer.
ACS Med Chem Lett 15: 777-778 (0)
Smith Gambrell & Russell LLP
Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen.
ACS Med Chem Lett 15: 791-797 (0)
AstraZeneca
Benzodioxane Carboxamide Derivatives As Novel Monoamine Oxidase B Inhibitors with Antineuroinflammatory Activity.
ACS Med Chem Lett 15: 798-805 (0)
Zunyi Medical University
Structure-Based Rational Design of Constrained Peptides as TIM-3 Inhibitors.
ACS Med Chem Lett 15: 806-813 (0)
Weill Cornell Medicine
Nonsymmetrically Substituted 1,1'-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction.
ACS Med Chem Lett 15: 828-836 (0)
Jagiellonian University
Structural Modifications of Covalent Cathepsin S Inhibitors: Impact on Affinity, Selectivity, and Permeability.
ACS Med Chem Lett 15: 837-844 (0)
Johannes Gutenberg University Mainz
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
ACS Med Chem Lett 15: 864-872 (0)
Genentech
Insight on Some Newly Synthesized Trisubstituted Imidazolinones as VEGFR-2 Inhibitors.
ACS Med Chem Lett 15: 892-898 (0)
Cairo University
2-Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain Model.
ACS Med Chem Lett 15: 917-923 (0)
Merck & Co.
Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors.
ACS Med Chem Lett 15: 945-949 (0)
University of Miami Miller School of Medicine
SARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme.
ACS Med Chem Lett 15: 950-957 (0)
Texas A&M University
Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors.
ACS Med Chem Lett 15: 958-964 (0)
Haihe Biopharma Co., Ltd.
Novel 2,4-Dichloro-5-sulfamoylbenzoic Acid Oxime Esters: First Studies as Potential Human Carbonic Anhydrase Inhibitors.
ACS Med Chem Lett 15: 972-978 (0)
MGM University
Novel Heterocyclic Compounds as Monoacylglycerol Lipase Inhibitors for Treating Multiple Diseases.
ACS Med Chem Lett 15: 994-995 (0)
Smith, Gambrell & Russell
Novel AHR Agonists for Treating Psoriasis and Atopic Dermatitis.
ACS Med Chem Lett 15: 996-997 (0)
Smith, Gambrell & Russell
Toward Precision Oncology: The Role of TPD in Targeting CDK2 and Beyond.
ACS Med Chem Lett 15: 1004-1006 (0)
Usona Institute
Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581.
ACS Med Chem Lett 15: 1010-1016 (0)
Daiichi Sankyo Co., Ltd.
Design Principle of Heparanase Inhibitors: A Combined In Vitro and In Silico Study.
ACS Med Chem Lett 15: 1032-1040 (0)
University of Florida
Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase.
ACS Med Chem Lett 15: 1088-1093 (0)
Marquette University
Novel Imidazopyridine and Imidazopyridazine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases.
ACS Med Chem Lett 15: 1180-1181 (0)
Smith, Gambrell & Russell
Novel Compounds as NLRP3 Inhibitors for Treating Cardiovascular Diseases.
ACS Med Chem Lett 15: 1184-1185 (0)
Smith, Gambrell & Russell
Novel Papain-Like Protease Inhibitors for Treating Viral Infections, in particular, Coronavirus Infections.
ACS Med Chem Lett 15: 1186-1187 (0)
Smith, Gambrell & Russell
Novel Cyanopyridine Compounds as KHK Inhibitors for Treating NAFLD, NASH, and Type II Diabetes.
ACS Med Chem Lett 15: 1191-1192 (0)
Smith, Gambrell & Russell
Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors.
ACS Med Chem Lett 15: 1196-1198 (0)
Usona Institute
Treatment of Metabolic Disorders Using Novel DGAT2 Inhibitors: Pyrazolopyridine and Triazolopyridine Derivatives.
ACS Med Chem Lett 15: 1199-1200 (0)
Usona Institute
Novel Compounds as NLRP3 Inhibitors for Treating Alzheimer's Disease and Parkinson's Disease.
ACS Med Chem Lett 15: 1203-1204 (0)
Smith, Gambrell & Russell
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity.
ACS Med Chem Lett 15: 1205-1212 (0)
Anhui University of Chinese Medicine
Design, Synthesis, and Biological Evaluation of 2,4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors.
ACS Med Chem Lett 15: 1213-1220 (0)
Shanghai Institute of Materia Medica
Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.
ACS Med Chem Lett 15: 1232-1241 (0)
Merck & Co.
Ligand-Based Pharmacophoric Design and Anti-inflammatory Evaluation of Triazole Linked Semisynthetic Labdane Conjugates.
ACS Med Chem Lett 15: 1260-1268 (0)
CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators.
ACS Med Chem Lett 15: 1279-1286 (0)
University of Minnesota
Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening.
ACS Med Chem Lett 15: 1287-1297 (0)
Ohio State University
Chemical Probes to Investigate Central Nervous System Disorders: Design, Synthesis and Mechanism of Action of a Potent Human Serine Racemase Inhibitor.
ACS Med Chem Lett 15: 1298-1305 (0)
University of Parma
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket.
ACS Med Chem Lett 15: 1319-1324 (0)
Lund University
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.
ACS Med Chem Lett 15: 1325-1333 (0)
University of North Carolina at Chapel Hill
Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PLpro).
ACS Med Chem Lett 15: 1351-1357 (0)
Vanderbilt University
Novel Azepino[4,5-b]indolone as cGAS Inhibitors for Treating Immune-Mediated Diseases.
ACS Med Chem Lett 15: 1417-1418 (0)
Smith, Gambrell & Russell
Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) as Treatment for Inflammatory Diseases.
ACS Med Chem Lett 15: 1421-1423 (0)
PI Health Sciences
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases.
ACS Med Chem Lett 15: 1424-1426 (0)
PI Health Sciences
Advancements in Targeted Therapeutics: Integrating Metabolic Modulation, Immune Engineering, and Biologic Formulation Technologies.
ACS Med Chem Lett 15: 1430-1432 (0)
Usona Institute
Novel Triazolopyridine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases.
ACS Med Chem Lett 15: 1435-1436 (0)
Smith, Gambrell & Russell
Current Trends in Psychedelic Science: Integrating Modified Lysergic Acid Derivatives and Psilocybin in Modern Medicine.
ACS Med Chem Lett 15: 1443-1445 (0)
Usona Institute
Highly Selective Novel Heme Oxygenase-1 Hits Found by DNA-Encoded Library Machine Learning beyond the DEL Chemical Space.
ACS Med Chem Lett 15: 1456-1466 (0)
WuXi AppTec (Shanghai) Co., Ltd.
Nicotinic Acid Derivatives As Novel Noncompetitive α-Amylase and α-Glucosidase Inhibitors for Type 2 Diabetes Treatment.
ACS Med Chem Lett 15: 1474-1481 (0)
University of Milan
Virtual Screening and Molecular Docking: Discovering Novel METTL3 Inhibitors.
ACS Med Chem Lett 15: 1491-1499 (0)
Hangzhou Medical College
Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases.
ACS Med Chem Lett 15: 1506-1515 (0)
University of Bologna
Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen.
ACS Med Chem Lett 15: 1526-1532 (0)
University of Missouri - Columbia
Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase-RNA interactions.
ACS Med Chem Lett 15: 1533-1540 (0)
"Sapienza" Universita di Roma
Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain.
ACS Med Chem Lett 15: 1559-1565 (0)
University of Florence
Side Chain Investigation of Imidazopyridazine as a Hinge Binder for Targeting Actionable Mutations of RET Kinase.
ACS Med Chem Lett 15: 1566-1574 (0)
Gachon University
Asymmetric Dirhodium-Catalyzed Modification of Immunomodulatory Imide Drugs and Their Biological Assessment.
ACS Med Chem Lett 15: 1575-1583 (0)
Emory University