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TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642014(CHEMBL5566400)
Affinity DataEC50:  110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642015(CHEMBL5574136)
Affinity DataEC50: >3.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642016(CHEMBL5570907)
Affinity DataEC50:  2.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642017(CHEMBL5566411)
Affinity DataEC50:  2.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642018(CHEMBL5566873)
Affinity DataEC50:  210nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642019(CHEMBL5564191)
Affinity DataEC50:  2.20E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642020(CHEMBL5542370)
Affinity DataEC50:  9.70E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642021(CHEMBL5566216)
Affinity DataEC50:  1.40E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642022(CHEMBL5569610)
Affinity DataEC50:  860nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642023(CHEMBL5566116)
Affinity DataEC50:  320nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642024(CHEMBL5542424)
Affinity DataEC50:  220nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642025(US12344595, Example 77)
Affinity DataEC50:  290nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642026(US12344595, Example 63)
Affinity DataEC50:  2.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642027(US12344595, Example 44)
Affinity DataEC50:  12nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642028(CHEMBL5572064)
Affinity DataEC50:  34nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642029(US12344595, Example 43)
Affinity DataEC50:  32nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642030(US12344595, Example 51)
Affinity DataEC50:  240nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642013(US12344595, Example 1)
Affinity DataEC50:  42nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642031(US12344595, Example 78)
Affinity DataEC50:  6nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732865(2-(4,4-difluoroazepan-1-yl)-6,7-difluoro-N-(3-sulf...)
Affinity DataIC50: 0.0710nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732865(2-(4,4-difluoroazepan-1-yl)-6,7-difluoro-N-(3-sulf...)
Affinity DataIC50: 0.0840nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732866(2-(4,4-difluoroazepan-1-yl)-6,7-difluoro-N-(2-sulf...)
Affinity DataIC50: 0.0950nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

LigandPNGBDBM71381(US9694002, 440 | US9546164, 440)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50547894(CHEMBL4760292 | US11377438, Example 172)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50547894(CHEMBL4760292 | US11377438, Example 172)
Affinity DataIC50: 0.300nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM686334(US20240246932, Example 22A)
Affinity DataIC50: 0.310nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732864(2-(4,4-difluoroazepan-1-yl)-N-(2-sulfamoylpyridine...)
Affinity DataIC50: 0.340nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732867(N-(3-carbamoyl-4-fluorophenyl)-2-(4,4-difluoroazep...)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50547925(CHEMBL4798938)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.8 expressed in HEK cells applied electrical stimulus 10 Hz for 10 seconds measuring relaxation to the resting state followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732863(N-(2-carbamoylpyridin-4-yl)-2-(4,4-difluoroazepan-...)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50547896(CHEMBL4777598 | US11377438, Example 184)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50547896(CHEMBL4777598 | US11377438, Example 184)
Affinity DataIC50: 0.5nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM686440(US20240246932, Example 79)
Affinity DataIC50: 0.580nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM754079(2-(azepan-1-yl)-5-chloro-4,6-dimethyl-N-(3-sulfamo...)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732864(2-(4,4-difluoroazepan-1-yl)-N-(2-sulfamoylpyridine...)
Affinity DataIC50: 0.725nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732863(N-(2-carbamoylpyridin-4-yl)-2-(4,4-difluoroazepan-...)
Affinity DataIC50: 0.784nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

LigandPNGBDBM71340(US9694002, 411 | US9546164, 411)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50547926(CHEMBL4753280)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human Nav1.8 expressed in HEK cells applied electrical stimulus 10 Hz for 10 seconds measuring relaxation to the resting state followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM529546(US11203571, Compound 98 | 2,4-dichloro-6-(4-chloro...)
Affinity DataIC50: 0.800nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM560005(US11377438, Example 53)
Affinity DataIC50: 0.800nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50547885(CHEMBL4781110 | US11377438, Example 18)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM529543(US11203571, Compound 95 | 2,4-dichloro-6-(4-fluoro...)
Affinity DataIC50: 0.900nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50547885(CHEMBL4781110 | US11377438, Example 18)
Affinity DataIC50: 0.900nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM732862(US20250115578, KH09 | US20250115578, Example 09)
Affinity DataIC50: 0.918nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50330935(N-(m-Tolyl)-6-(4-ethoxyphenyl)-pyrazine-2-carboxam...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM181203(US9139529, 46 | US9783501, Compound 46)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
Go to US Patent

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