Compile Data Set for Download or QSAR
Report error Found 97 of affinity data for UniProtKB/TrEMBL: Q00024
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195552(4-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl...)
Affinity DataIC50: 36nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM240726(US9422261, Compound 4)
Affinity DataIC50: 80nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM240723(US9422261, Compound 1)
Affinity DataIC50: 90nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM240731(US9422261, 4-(1- phenylethyl) benzene-1,3- diol)
Affinity DataIC50: 100nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM240725(US9422261, Compound 3)
Affinity DataIC50: 200nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473792(1-(3-methyl-2,4-dimethoxyphenyl)-3-(2′,4R...)
Affinity DataIC50: 240nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195551(4-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl...)
Affinity DataIC50: 255nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM240724(US9422261, Compound 2)
Affinity DataIC50: 400nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195553(4-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl...)
Affinity DataIC50: 473nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473767(1-(2,4-dihydroxyphenyl)-3-(3',4'-dihydroxyphenyl)-...)
Affinity DataIC50: 500nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195547(2-((2-Nitrobenzylidene)amino)-5-mercapto-1,3,4-thi...)
Affinity DataIC50: 671nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473769(1-(2,4-dihydroxyphenyl)-3-(2'-hydroxyphenyl)-1-pro...)
Affinity DataIC50: 700nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195548(2-((2-Methoxybenzylidene)amino)-5-mercapto-1,3,4-t...)
Affinity DataIC50: 733nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195540(2-((2-Fluorobenzylidene)amino)-5-mercapto-1,3,4-th...)
Affinity DataIC50: 765nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195550(2-(((5-Mercapto-1,3,4-thiadiazol-2-yl)imino)methyl...)
Affinity DataIC50: 785nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473768(1-(2,4-dihydroxyphenyl)-3-(3',4'-dimethoxyphenyl)-...)
Affinity DataIC50: 850nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195554(2-((2,4,6-Trimethoxybenzylidene)amino)-5-mercapto-...)
Affinity DataIC50: 907nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM50248158(N-butylresorcinol | CHEMBL450195 | US8993596, 4-Bu...)
Affinity DataIC50: 1.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM233168(N-(2-Hydroxy-ethyl)-3,5-dinitro-benzamide (7))
Affinity DataIC50: 1.09E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195546(2-((4-(Tert-butyl)benzylidene)amino)-5-mercapto-1,...)
Affinity DataIC50: 1.39E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM234394(Polyhydroxy benzophenone, 10)
Affinity DataIC50: 1.40E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM240727(US9422261, Compound 5)
Affinity DataIC50: 1.50E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195544(4-Chloro-2-(((5-mercapto-1,3,4-thiadiazol-2-yl)imi...)
Affinity DataIC50: 1.72E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195545(4-Bromo-2-(((5-mercapto-1,3,4-thiadiazol-2-yl)imin...)
Affinity DataIC50: 1.97E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM240729(US9422261, Unigen resorcinol derivative | US968291...)
Affinity DataIC50: 2.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM233170(N-Hydroxy-4,N-dimethyl-benzamide (9))
Affinity DataIC50: 2.09E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195542(2-((4-Chlorobenzylidene)amino)-5-mercapto-1,3,4-th...)
Affinity DataIC50: 2.46E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473770(1-(2,4-dihydroxyphenyl)-3-(2'-methoxyphenyl)-1-pro...)
Affinity DataIC50: 3.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM233169(N-(2-Bromo-ethyl)-3,5-dinitro-benzamide (8))
Affinity DataIC50: 3.08E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195543(2-((3,4-Dichlorobenzylidene)amino)-5-mercapto-1,3,...)
Affinity DataIC50: 3.62E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM50198715(CHEMBL245416 | L-mimosine | (2S)-2-amino-3-(3-hydr...)
Affinity DataIC50: 3.68E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195541(2-((3-Chlorobenzylidene)amino)-5-mercapto-1,3,4-th...)
Affinity DataIC50: 4.75E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM240730(US9422261, Unigen resorcinol derivative | US968291...)
Affinity DataIC50: 4.90E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM195549(2-((3,5-Dimethoxybenzylidene)amino)-5-mercapto-1,3...)
Affinity DataIC50: 5.35E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473771(1-(2,4-dihydroxyphenyl)-3-(4'-methoxyphenyl)-1-pro...)
Affinity DataIC50: 6.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM234393(Polyhydroxy benzophenone, 9)
Affinity DataIC50: 6.40E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM50249353(1,1,3-trihydroxybenzophenone | 2,2',4-trihydroxybe...)
Affinity DataIC50: 7.30E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473773(1-(2,4-dihydroxyphenyl)-3-phenyl-1-propanol | US10...)
Affinity DataIC50: 8.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473772(1-(2,4,6-trihydroxyphenyl)-3-(4'-aminophenyl)-1-pr...)
Affinity DataIC50: 8.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473774(1-(2,4-dihydroxyphenyl)-3-(3'-methoxy-4'-hydroxyph...)
Affinity DataIC50: 8.50E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM234397(Polyhydroxy benzophenone, 15)
Affinity DataIC50: 8.80E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM225847(hsp90_138 | Polyhydroxy benzophenone, 8)
Affinity DataIC50: 1.01E+4nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM50234650(phenyl(2,3,4-trihydroxyphenyl)methanone | 2,3,4-tr...)
Affinity DataIC50: 1.05E+4nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM473775(1-(2-hydroxy-4-methoxyphenyl)-3-(3',4',5'-trimetho...)
Affinity DataIC50: 1.10E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM233171(N-Ethyl-benzamide (10))
Affinity DataIC50: 1.18E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM233166(3-Methyl-2-butenyl-4-hydroxybenzoate (2))
Affinity DataIC50: 1.48E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM50031467(Kojic Acid | CHEMBL287556 | 5-HYDROXY-2-(HYDROXYME...)
Affinity DataIC50: 1.50E+4nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM50031467(Kojic Acid | CHEMBL287556 | 5-HYDROXY-2-(HYDROXYME...)
Affinity DataIC50: 1.67E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1(White button mushroom)
Pierre Fabre Dermo-Cosmetique

US Patent
LigandPNGBDBM234392(Polyhydroxy benzophenone, 6)
Affinity DataIC50: 1.74E+4nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetPolyphenol oxidase 1 [61-568](White button mushroom)
Shaoyang University

LigandPNGBDBM50031467(Kojic Acid | CHEMBL287556 | 5-HYDROXY-2-(HYDROXYME...)
Affinity DataIC50: 2.36E+4nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
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