Compile Data Set for Download or QSAR
Report error Found 554 of affinity data for UniProtKB/TrEMBL: Q9Z1M0
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50585248(CHEMBL2338352)
Affinity DataIC50: 0.650nMAssay Description:Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174795(US9102686, 26 | US9540388, 26 | US10053462, 26)
Affinity DataIC50: 1.40nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246942((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataIC50: 1.40nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM203318(US10053462, 196 | US9540388, 196 | (6r,10s)-11-{[2...)
Affinity DataIC50: 1.70nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174777(US9102686, 8 | US9540388, 8 | US10053462, 8)
Affinity DataIC50: 2.5nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246956((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-8-(4-m...)
Affinity DataIC50: 2.70nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246964((S)-3-[2-chloro-3-(trifluoromethyl)phenyl]-5-methy...)
Affinity DataIC50: 3.90nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246967((S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methy...)
Affinity DataIC50: 4.20nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174787(US9102686, 18 | US9540388, 18 | US10053462, 18)
Affinity DataIC50: 4.40nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174770(US9102686, 1 | US9540388, 1 | US10053462, 1)
Affinity DataIC50: 4.5nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM160123(US10047092, 64 | US9040534, 64 | US10053463, 64)
Affinity DataIC50: 4.60nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM160133(US10047092, 74 | US9040534, 74 | US10053463, 74)
Affinity DataIC50: 5.10nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM160130(US9040534, 72 | US10047092, 72 | US9040534, 71 | U...)
Affinity DataIC50: 5.60nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246954((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataIC50: 5.70nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM160087(US10047092, 28 | US9040534, 28 | US10053463, 28)
Affinity DataIC50: 6.90nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246968((S)-3-(2-chloro-3-(trifluoromethyl)phenyl)-5-methy...)
Affinity DataIC50: 7.20nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM203315(US10053462, 194 | US9540388, 194 | (6r,10s)-11-{[2...)
Affinity DataIC50: 7.40nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174772(US9102686, 3 | US9540388, 3 | US10053462, 3)
Affinity DataIC50: 8.10nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174783(US9102686, 14 | US9540388, 14 | US10053462, 14)
Affinity DataIC50: 8.20nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM160125(US10047092, 66 | US9040534, 66 | US10053463, 66)
Affinity DataIC50: 8.20nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50237707(A-804598 | CHEMBL1628690)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at mouse P2X7 receptor expressed in 1321N1 cells assessed as inhibition of agonist-induced calcium flux pretreated for 3 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50298708([3H]A-804598 | CHEMBL574539)
Affinity DataIC50: 9nMAssay Description:Antagonist activity against mouse P2X7R expressed in human 1321N1 cell membrane incubated for 1 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM160122(US10047092, 63 | US9040534, 63 | US10053463, 63)
Affinity DataIC50: 9.60nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50298708([3H]A-804598 | CHEMBL574539)
Affinity DataIC50: 10nMAssay Description:Binding affinity at mouse P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50627925(CHEMBL5398672)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation by propidium iodid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM203331(US10053462, 200 | US9540388, 200 | (6r,10s)-11-{[2...)
Affinity DataIC50: 10.2nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246945((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-8-(5-f...)
Affinity DataIC50: 10.2nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM227806((6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethy...)
Affinity DataIC50: 10.3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM160094(US10047092, 35 | US9040534, 35 | US10053463, 35)
Affinity DataIC50: 10.6nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174802(US9102686, 33 | US9540388, 32 | US10053462, 33)
Affinity DataIC50: 11.3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246948((5S)-3-[2-Chloro-3-(trifluoromethyl)phenyl]-5-meth...)
Affinity DataIC50: 11.3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649300(2-Chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 11.3nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649255(2-Chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 11.5nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM160127(US10047092, 68 | US9040534, 68 | US10053463, 68)
Affinity DataIC50: 11.8nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50627924(CHEMBL5431276)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation by propidium iodid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649223(N-{2-[4-(1,3-Benzoxazol-2-yloxy)piperidin-1-yl]-2-...)
Affinity DataIC50: 12.3nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM203324(US10053462, 199 | US9540388, 199 | (6r,10s)-11-{[3...)
Affinity DataIC50: 12.7nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649268(2-Chloro-N-(2-{4-[(6-chloropyridin-2-yl)oxy]piperi...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at mouse P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649268(2-Chloro-N-(2-{4-[(6-chloropyridin-2-yl)oxy]piperi...)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse P2X7 receptor expressed in HEK293 cells incubated for 5 mins followed by Bz-ATP addition measured after 3 mins by fluorescence ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649293(2-Chloro-N-[2-(4-{[(3-cyanopyridin-2-yl)oxy]methyl...)
Affinity DataIC50: 13.2nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649268(2-Chloro-N-(2-{4-[(6-chloropyridin-2-yl)oxy]piperi...)
Affinity DataIC50: 13.4nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174818(US9102686, 49 | US9540388, 49 | US10053462, 49)
Affinity DataIC50: 13.5nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246970((S)-3-(2,4-dichlorophenyl)-8-(5-fluoropyridin-2-yl...)
Affinity DataIC50: 13.7nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649283(2-Chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 13.8nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649222(N-{2-[4-(1,3-Benzothiazol-2-yl oxy)piperidin-1-yl]...)
Affinity DataIC50: 14nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649222(N-{2-[4-(1,3-Benzothiazol-2-yl oxy)piperidin-1-yl]...)
Affinity DataIC50: 14nMAssay Description:Inhibition of mouse P2X7 receptor expressed in HEK293 cells incubated for 5 mins followed by Bz-ATP addition measured after 3 mins by fluorescence ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM174774(US9102686, 5 | US9540388, 5 | US10053462, 5)
Affinity DataIC50: 14.7nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246962((S)-3-[2-chloro-3-(trifluoromethyl)phenyl]-5-methy...)
Affinity DataIC50: 14.9nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM246973((S)-3-(2,4-dichlorophenyl)-8-(4-methoxypyridin-2-y...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM649284(2-Chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 15.2nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

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