Compile Data Set for Download or QSAR
Report error Found 21 for UniProtKB: Q9ULW0
LigandPNGBDBM109207(Compound II: Ac-D-Arg6-D-Lys(PromoFluor 647)-D-Lys...)
Affinity DataKd:  4.34nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
LigandPNGBDBM109208(2-[(1E,3E)-5-[(2E)-3-(3-{[(5R)-5-carbamoyl-5-{[4- ...)
Affinity DataKd:  0.544nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
LigandPNGBDBM109206(2-[(1E,3E)-5-[(2E)-3-(3-{[(5R)-5-carbamoyl-5-[(4- ...)
Affinity DataKd:  0.527nMT: 2°CAssay Description:A stock solution was prepared containing complex of Aurora A and Compound I (final total concentrations of 6nM and 5nM, respectively). Separately, se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
TargetAurora kinase A/Targeting protein for Xklp2(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM209861(TAK-901 | 5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N...)
Affinity DataIC50: 21nMAssay Description:Inhibition of Aurora A/TPX2 (unknown origin) pre-incubated for 1 hr followed by FL-Kemptide substrate and ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700780(6-(2-chlorobenzyl)-2-(4-ethylpiperazin-1-yl)-5,6,7...)
Affinity DataIC50: 1.50E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700779(2-(4-ethylpiperazin-1-yl)-6-(2,3,4-trimethoxybenzy...)
Affinity DataIC50: 1.70E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700778(2-(4-ethylpiperazin-1-yl)-6-(2,4,5-trimethoxybenzy...)
Affinity DataIC50: 2.40E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700781(2-(4-ethylpiperazin-1-yl)-6-(3,4,5-trimethoxybenzy...)
Affinity DataIC50: 2.50E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700777(6-(3,4-diethoxybenzyl)-2-(4-ethylpiperazin-1-yl)-5...)
Affinity DataIC50: 2.80E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700782(6-(4-ethoxy-3-methoxybenzyl)-2-(4-ethylpiperazin-1...)
Affinity DataIC50: 3.50E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700784(4-allyl-2-methyl-N-(pyridin-2-ylmethyl)-4H-thieno[...)
Affinity DataIC50: 5.60E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700776(6-(4-bromobenzyl)-2-(4-propylpiperazin-1-yl)-5,6,7...)
Affinity DataIC50: 1.36E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700775(6-(3-bromobenzyl)-2-(4-propylpiperazin-1-yl)-5,6,7...)
Affinity DataIC50: 2.10E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700774(6-((5-bromothiophen-2-yl)methyl)-2-(4-propylpipera...)
Affinity DataIC50: 2.30E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700772(6-(2,3-difluorobenzyl)-2-(4-propylpiperazin-1-yl)-...)
Affinity DataIC50: 2.78E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700771(6-(4-ethylbenzyl)-2-(4-propylpiperazin-1-yl)-5,6,7...)
Affinity DataIC50: 3.22E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700773(6-(3,4-diethoxybenzyl)-2-(4-propylpiperazin-1-yl)-...)
Affinity DataIC50: 4.22E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700783(6-(4-ethoxy-3-methoxybenzyl)-2-(4-propylpiperazin-...)
Affinity DataIC50: 4.48E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

LigandPNGBDBM50277545(Alisertib | MLN8237 | CHEMBL483158 | 4-(9-chloro-7...)
Affinity DataKi:  1.86nM ΔG°:  -50.7kJ/mole IC50: 1.78E+3nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
LigandPNGBDBM109209(VX-689)
Affinity DataKi:  2.17nM ΔG°:  -50.3kJ/mole IC50: 2.07E+3nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2014
Entry Details Article
PubMed
TargetTargeting protein for Xklp2(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataKi:  490nMAssay Description:Inhibition of human Aurora A/TPX2 (unknown origin) pre-incubated for 30 mins before Biotin-Ahx-RARRRLSFFFFAKKK-NH2 substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed