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TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50255753(MK-0822 | Odanacatib | CHEMBL481611)
Affinity DataIC50: 10nMAssay Description:Inhibition of cathepsin ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303441(9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...)
Affinity DataIC50: 316nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 933nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303417(4-(Cyclopentylamino)-6-(3,5-difluorophenylamino)-1...)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303410(4-(3-chlorophenylamino)-6-(cyclopentylamino)-1,3,5...)
Affinity DataIC50: 6.46E+3nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551801(CHEMBL4754916)
Affinity DataIC50: 7.13E+3nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551800(CHEMBL4743093)
Affinity DataIC50: 9.54E+3nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453332(BDBM553835 | US10730826, Compound 69a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM397464(US9988375, Compound 43 | US10676470, Compound 43 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2022
Entry Details
Go to US Patent

TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453332(BDBM553835 | US10730826, Compound 69a)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM453275(US10730826, Compound 1a-non-racemic | US10730826, ...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM397464(US9988375, Compound 43 | US10676470, Compound 43 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302107(Grassystatin A | CHEMBL567893)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cathepsin Z after 10 to 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551796(CHEMBL4798763)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551797(CHEMBL1331625)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551798(CHEMBL4752735)
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50551799(CHEMBL4744124)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50303436(9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...)
Affinity DataIC50: 1.48E+4nMAssay Description:Inhibition of human Cathepsin X/ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCathepsin Z(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50195235(CHEMBL3900409 | US10287258, Example 2 | US10669245...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant cathepsin ZMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2018
Entry Details Article
PubMed