Compile Data Set for Download or QSAR
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TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM8903(CHEMBL103 | (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15...)
Affinity DataKd:  239nMAssay Description:Displacement of [3H]pentazocine from sigma-1 opioid receptor in rat liver membranes after 1 hr by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179271(CHEMBL175560 | CHEMBL535366 | 1-(4-(6-methoxynapht...)
Affinity DataEC50:  1.94E+4nMAssay Description:Antiproliferative activity mediated by sigma 1 receptor in rat C6 glioma cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL521582 | [2-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataEC50:  1.07E+4nMAssay Description:Antiproliferative activity mediated by sigma 1 receptor in rat C6 glioma cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179277(CHEMBL544343 | CHEMBL323056 | 1-(4-(6-methoxynapht...)
Affinity DataEC50:  1.50E+4nMAssay Description:Antiproliferative activity mediated by sigma 1 receptor in rat C6 glioma cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179280(CHEMBL176941 | CHEMBL545278 | 1-(4-(6-methoxynapht...)
Affinity DataEC50:  2.55E+4nMAssay Description:Antiproliferative activity mediated by sigma 1 receptor in rat C6 glioma cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50179260(CHEMBL537177 | 1-(3-(6-methoxynaphthalen-1-yl)prop...)
Affinity DataEC50:  4.02E+4nMAssay Description:Antiproliferative activity mediated by sigma 1 receptor in rat C6 glioma cells by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50225931(CHEMBL3038191)
Affinity DataEC50:  180nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataEC50:  3nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225932(CHEMBL2310918)
Affinity DataEC50:  90nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225933(CHEMBL2310921)
Affinity DataEC50:  6nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225934(CHEMBL2310922)
Affinity DataEC50:  100nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225935(CHEMBL2310915)
Affinity DataEC50:  7nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225936(CHEMBL3038190)
Affinity DataEC50:  7nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225937(CHEMBL3038189)
Affinity DataEC50:  6nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225938(CHEMBL2310919)
Affinity DataEC50:  100nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225939(CHEMBL3038192)
Affinity DataEC50:  130nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225940(CHEMBL2310917)
Affinity DataEC50:  50nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50367061(NALORPHINE HYDROCHLORIDE | NALORPHINE)
Affinity DataEC50:  1.5nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225941(CHEMBL2310920)
Affinity DataEC50:  130nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50225942(CHEMBL2310916)
Affinity DataEC50:  90nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2018
Entry Details Article
PubMed
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataKd:  154nMAssay Description:Compound was evaluated for opioid receptor affinity against the receptor site model site 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50021328(CHEMBL149414 | 3-Cyclopropylmethyl-11-ethyl-8-hydr...)
Affinity DataKd:  4.16E+3nMAssay Description:Compound was evaluated for opioid receptor affinity against the receptor site model site 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50452273(Dihydromorphine)
Affinity DataKd:  200nMAssay Description:Compound was evaluated for opioid receptor affinity against the receptor site model site 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50021322(3-(3-Methyl-1-phenethyl-piperidin-3-yl)-phenol | C...)
Affinity DataKd:  2.63E+4nMAssay Description:Opioid receptor affinity against the receptor site model site 5 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50021322(3-(3-Methyl-1-phenethyl-piperidin-3-yl)-phenol | C...)
Affinity DataKd:  2.63E+4nMAssay Description:Opioid receptor affinity against the receptor site model site 5 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50021323(CHEMBL151270 | 3-(1-Allyl-3-methyl-piperidin-3-yl)...)
Affinity DataKd:  3.70E+3nMAssay Description:Opioid receptor affinity against the receptor site model site 5 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50021323(CHEMBL151270 | 3-(1-Allyl-3-methyl-piperidin-3-yl)...)
Affinity DataKd:  3.70E+3nMAssay Description:Opioid receptor affinity against the receptor site model site 5 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50021324(3-(1-Cyclopropylmethyl-3-methyl-piperidin-3-yl)-ph...)
Affinity DataKd:  833nMAssay Description:Opioid receptor affinity against the receptor site model site 5 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50021324(3-(1-Cyclopropylmethyl-3-methyl-piperidin-3-yl)-ph...)
Affinity DataKd:  833nMAssay Description:Opioid receptor affinity against the receptor site model site 5 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50021327(CHEMBL359154 | 3-(1,3-Dimethyl-piperidin-3-yl)-phe...)
Affinity DataKd:  8.33E+3nMAssay Description:Opioid receptor affinity against the receptor site model site 5 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50021327(CHEMBL359154 | 3-(1,3-Dimethyl-piperidin-3-yl)-phe...)
Affinity DataKd:  8.33E+3nMAssay Description:Opioid receptor affinity against the receptor site model site 5 by using the curve-fitting program LIGANDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKd:  1.00E+4nMAssay Description:Compound was evaluated for opioid receptor affinity against the receptor site model site 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50: 0.00300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 0.00400nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataIC50: 0.00400nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 0.00900nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50001707(Tylox | Oxycet | Combunox | Codoxy | Percocet | 10...)
Affinity DataIC50: 0.0130nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225845(CHEMBL293967)
Affinity DataIC50: 0.0150nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50225204(CHEMBL606711)
Affinity DataIC50: 0.0200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.0270nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.0500nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50035145(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50035141(1'-(cyclohexylbutyl)-3H-spiro[2-benzofuran-1,4'-pi...)
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50: 0.0800nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225211(CHEMBL606767)
Affinity DataIC50: 0.0850nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50054124(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50: 0.0890nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50054124(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50: 0.0890nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50035105(Siramesine | Lu 28-179 | 1'-{4-[1-(4-fluorophenyl)...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Washington University

Curated by ChEMBL
LigandPNGBDBM50035133(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50: 0.140nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50001707(Tylox | Oxycet | Combunox | Codoxy | Percocet | 10...)
Affinity DataIC50: 0.150nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
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