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TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human partial length CDK12 (P697 to E1077 residues) expressed in mammalian expression system measured after 1 hr by kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478281(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478326(US10894786, Comp. No 6 | 2-(1''-acryloyl-1'',2'',3...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478327(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478328((S)-2-(4-(1-acryloylpiperidin-4-yl)phenyl)-N-(5-cy...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478329(2-(6-(1-acryloylpiperidin-4-yl)pyridin-3-yl)-N-(5-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478330((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478350((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478351((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478354(2-(6-(4-acryloylpiperazin-1-yl)pyridin-3-yl)-N-(5-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478360(N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478422((S)-2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-y...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478430(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478485((S)-2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-y...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478489(N-(4'-(1 ((5-cyclopropyl-1H-pyrazol-3-yl)amino)-1-...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478491(2-(4-(1-acryloyl-2,3,6,7-tetrahydro-1H-azepin-4-yl...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478666(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478758(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478782(US10894786, Comp. No 36 | US10894786, Comp. No 37 ...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478800(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478893(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478931(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478932(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMAssay Description:Binding affinity to CDK12 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMAssay Description:Binding affinity to partial length human wild-type CDK12 expressed in mammalian expression system assessed as dissociation constant by DiscoverX KINO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)
Affinity DataKd:  16nMAssay Description:Binding affinity to human CDK12 (715 to 1052 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50594507(CHEMBL5203891)
Affinity DataKd:  27nMAssay Description:Binding affinity to human CDK12 (715 to 1052 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMAssay Description:Binding affinity to CDK12 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50154937(CHEMBL518800)
Affinity DataEC50:  16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644786(CHEMBL5573271)
Affinity DataEC50:  78nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50378235(CHEMBL461557)
Affinity DataEC50:  17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50479452(CHEMBL461556)
Affinity DataEC50:  36nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644787(CHEMBL5565816)
Affinity DataEC50:  28nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644788(CHEMBL5573487)
Affinity DataEC50:  15nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644789(CHEMBL5593913)
Affinity DataEC50:  44nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644790(CHEMBL5575056)
Affinity DataEC50:  21nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataEC50:  703nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644791(CHEMBL5565299)
Affinity DataEC50:  60nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644792(CHEMBL5563303)
Affinity DataEC50:  182nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644793(CHEMBL5592449)
Affinity DataEC50:  57nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644794(CHEMBL5575551)
Affinity DataEC50:  18nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644795(CHEMBL5594035)
Affinity DataEC50:  21nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644796(CHEMBL5568619)
Affinity DataEC50:  35nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644797(CHEMBL5569096)
Affinity DataEC50:  36nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644798(CHEMBL5574391)
Affinity DataEC50:  46nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644799(CHEMBL5568703)
Affinity DataEC50:  246nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644800(CHEMBL5594597)
Affinity DataEC50:  603nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50644801(CHEMBL5569293)
Affinity DataEC50:  41nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50466842(CHEMBL1615221)
Affinity DataEC50:  16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
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