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TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50519158(CHEMBL4445812)
Affinity DataKd:  8.02E+3nMAssay Description:Binding affinity to wild-type human partial length CDK12 (P697 to E1077 residues) expressed in mammalian expression system measured after 1 hr by kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478281(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478326(US10894786, Comp. No 6 | 2-(1''-acryloyl-1'',2'',3...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478327(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478328((S)-2-(4-(1-acryloylpiperidin-4-yl)phenyl)-N-(5-cy...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478329(2-(6-(1-acryloylpiperidin-4-yl)pyridin-3-yl)-N-(5-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478330((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478350((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478351((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478354(2-(6-(4-acryloylpiperazin-1-yl)pyridin-3-yl)-N-(5-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478360(N-(1-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478422((S)-2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-y...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478430(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478485((S)-2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-y...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478489(N-(4'-(1 ((5-cyclopropyl-1H-pyrazol-3-yl)amino)-1-...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478491(2-(4-(1-acryloyl-2,3,6,7-tetrahydro-1H-azepin-4-yl...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478666(N-(4-(4-(1-((5-cyclopropyl-1H-pyrazol-3-yl)amino)-...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478758(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478782(US10894786, Comp. No 36 | US10894786, Comp. No 37 ...)
Affinity DataKd:  63nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478800(2-(4-(1-acryloyl-1,2,3,6-tetrahydropyridin-4-yl)ph...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478893(2-(1'-acryloyl-1',2',3',6'-tetrahydro-[2,4'-bipyri...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478931(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478932(2-(4-(4-acryloylpiperazin-1-yl)phenyl)-N-(5-cyclop...)
Affinity DataKd: >100nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMAssay Description:Binding affinity to CDK12 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMAssay Description:Binding affinity to partial length human wild-type CDK12 expressed in mammalian expression system assessed as dissociation constant by DiscoverX KINO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50367676(CHEMBL4160662)
Affinity DataKd:  16nMAssay Description:Binding affinity to human CDK12 (715 to 1052 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50594507(CHEMBL5203891)
Affinity DataKd:  27nMAssay Description:Binding affinity to human CDK12 (715 to 1052 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50584000(CHEMBL4877117)
Affinity DataKd:  98nMAssay Description:Binding affinity to CDK12 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724589(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 3.09nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478960(2-(1'-cyano-1',2',3',6'-tetrahydro-[2,4'-bipyridin...)
Affinity DataIC50: 4nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724595(2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyri...)
Affinity DataIC50: 4.14nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724593(2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyri...)
Affinity DataIC50: 5.96nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478959(2-(1'-cyano-1',2',5',6'-tetrahydro-[2,3'-bipyridin...)
Affinity DataIC50: 6nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM706362(US20240383900, Compound PPA-024)
Affinity DataIC50: 6nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-tagged human CDK12/Cyclin K expressed in Sf9 cells using RBER-IRStide peptide as substrate in presence of ATP and [gamma33-P] ATP b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724587(2-(morpholin-4-yl)-N-({5-[4-(trifluoromethoxy)phen...)
Affinity DataIC50: 7.59nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724585(2-(morpholin-4-yl)-N-({5-[4-(trifluoromethoxy)phen...)
Affinity DataIC50: 8.34nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478942(US10894786, Comp. No 44 | US10894786, Comp. No 45 ...)
Affinity DataIC50: 9nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724586(2-(morpholin-4-yl)-8-(trifluoromethyl)-N-({5-[4-(t...)
Affinity DataIC50: 9.21nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478951(2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridi...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM706422(US20240383900, Compound PPA-086)
Affinity DataIC50: 11nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724596(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 11.9nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478958(N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(6-(1-propiolo...)
Affinity DataIC50: 12nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724590(N-{[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl}-2...)
Affinity DataIC50: 12.3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50367857(CHEMBL4159417)
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM706428(US20240383900, Compound PPA-092)
Affinity DataIC50: 13nMAssay Description:A radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM478940(2-(4-(1-acryloyl-1,2,5,6-tetrahydropyridin-3-yl)-3...)
Affinity DataIC50: 14nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50540077(CHEMBL4649135)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged recombinant human CDK12 (696 to 1082 residues) expressed in Insect cell in presence of ATP by Km ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50583918(CHEMBL4791134)
Affinity DataIC50: 15nMAssay Description:Inhibition of CDK12/cyclin K (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandPNGBDBM724599(2-(morpholin-4-yl)-8-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 15.1nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

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