Compile Data Set for Download or QSAR
Report error Found 31 of affinity data for UniProtKB/TrEMBL: Q9JL18
TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50510991(CHEMBL4564735)
Affinity DataEC50:  40nMAssay Description:Inhibition of BACE2 in mouse B16-F1 cells assessed as increase in intracellular PMEL17 Mbeta accumulation measured after 4 days by Western blot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165913(US9067924, 7)
Affinity DataIC50: 2nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165910(US9067924, 4)
Affinity DataIC50: 4nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165909(US9067924, 3)
Affinity DataIC50: 5nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50570460(CHEMBL4854629)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of BACE2 in mouse MIN6 cells expressing wild type TMEM27 assessed as reduction in TMEM27 secretion by MSD electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165912(US9067924, 6)
Affinity DataIC50: 9nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165914(US9067924, 8)
Affinity DataIC50: 16nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486437((2R,5R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluor...)
Affinity DataIC50: 17nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165911(US9067924, 5)
Affinity DataIC50: 21nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486443((2R,5R)-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50: 33nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165908(US9067924, 2)
Affinity DataIC50: 79nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486438(6-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50: 95nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165907(US9067924, 1)
Affinity DataIC50: 167nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165916(US9067924, 10)
Affinity DataIC50: 181nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486439(5-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50: 273nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50579806(CHEMBL5092328)
Affinity DataIC50: 309nMAssay Description:Inhibition of BACE2 in mouse MIN6 cells expressing TMEM27 assessed as reduction in TMEM27 secretion incubated for 24 hrs by MSD electrochemiluminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486442((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50: 375nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486435((1R,5S,6R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50: 421nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486434((1R,5S,6R)-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-flu...)
Affinity DataIC50: 564nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486453(6-((Z)-2-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50: 853nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM165915(US9067924, 9)
Affinity DataIC50: 858nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486445((4R,5R)-4-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50: 1.51E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486441((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,3,3-...)
Affinity DataIC50: 1.59E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486436(6-((Z)-2-(3-((1R,5S,6R)-3-amino-5-(difluoromethyl)...)
Affinity DataIC50: 1.62E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50: 2.73E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486444(6-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50: 3.87E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486451((R,Z)-5,5-difluoro-4-(2-fluoro-5-(2-fluoro-2-(5-(p...)
Affinity DataIC50: 5.84E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486448(5-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50: 6.36E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486452((R,Z)-6-(2-(6-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50: 1.14E+4nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486446((4R,5R)-4-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50: 1.60E+4nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM486449((4R,5R)-4-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2...)
Affinity DataIC50: 1.71E+4nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent