Compile Data Set for Download or QSAR
Report error Found 7 for UniProtKB: Q9HB55
TargetCytochrome P450 3A43(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252659((S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrr...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A43(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM562067(US11396516, Example 2)
Affinity DataIC50: 9.30E+3nMAssay Description:The ability of the tested compounds to inhibit a panel of CYP enzymes in vitro was assessed using a series of human liver microsome assays. Half-maxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
Go to US Patent

TargetCytochrome P450(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50508661(CHEMBL4524830)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50464556(CHEMBL4289811 | US10464907, Compound 21f | US10889...)
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of CYP3A in human pooled human liver microsomes using midazolam as substrate assessed as midazolam 1'-hydroxylation preincubated for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of CYP3A in human liver microsomes assessed as reduction in midazolam 1'-hydroxylation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50527104(CHEMBL4447583)
Affinity DataIC50: 6.22E+4nMAssay Description:Inhibition of CYP3A in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50527104(CHEMBL4447583)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed