Compile Data Set for Download or QSAR
Report error Found 21 of affinity data for UniProtKB/TrEMBL: Q9EPK8
LigandPNGBDBM50277488(4alpha-Phorbol 12,13-dioctanoate | CHEMBL507303)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50545035(CHEMBL4303584)
Affinity DataEC50:  770nMAssay Description:Agonist activity at mouse TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545034(CHEBI:34450 | CHEMBL1893588)
Affinity DataEC50:  150nMAssay Description:Agonist activity at mouse TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50240777(Decanoic acid (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9-de...)
Affinity DataEC50:  370nMAssay Description:Agonist activity at mouse TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50545036(CHEMBL4632531)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at mouse TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50277740(4-Deoxy-4alpha-Phorbol 12,13-didecanoate | CHEMBL5...)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50277489(4alpha-Phorbol 12,13-dinonanoate | CHEMBL130626)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50277739(4alpha-phorbol diacetate | CHEMBL484343)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataEC50:  2.25E+4nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50277490(4alpha-Phorbol 12,13-dimyristate | CHEMBL451849)
Affinity DataEC50:  2.83E+3nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50277486(4alpha-Phorbol 13-decanoate | CHEMBL541720)
Affinity DataEC50:  450nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50240777(Decanoic acid (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9-de...)
Affinity DataEC50:  370nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50277491(Lumi-4alpha-Phorbol 12,13-didecanoate | CHEMBL5049...)
Affinity DataEC50:  175nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50277487(4alpha-Phorbol 12,13-dihexanoate | CHEMBL490470)
Affinity DataEC50:  70nMAssay Description:Activation of mouse wild type TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50192821(CHEMBL2133556)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced current at holding potential of -40 mV by W...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50192821(CHEMBL2133556)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50117636(CHEMBL3613642)
Affinity DataIC50: 57nMAssay Description:Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50117636(CHEMBL3613642)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50426575(CHEMBL2324347)
Affinity DataIC50: 5.90E+3nMAssay Description:Antagonist activity at mouse TRPV4 expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-induced intracellular calcium after 10 mins in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2019
Entry Details Article
PubMed
LigandPNGBDBM50426575(CHEMBL2324347)
Affinity DataIC50: 5.90E+3nMAssay Description:Antagonist activity at mouse TRPV4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM85747(CLEMIZOLE HYDROCHLORIDE | NSC_2782 | CAS_442-52-4 ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of YFP-tagged mouse TRPV4 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed