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TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50089221(CHEMBL3577854)
Affinity DataKd:  2.50E+4nMAssay Description:Binding affinity to human full length PRMT5-MEP50 complex by Surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataKd:  987nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2019
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50366992(CHEMBL4168754)
Affinity DataKd:  6nMAssay Description:Inhibition of PRMT5/MEP50 complex (unknown origin) expressed in Sf9 insect cells using SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin as substrate by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50506814(CHEMBL4513619)
Affinity DataKd:  1.08E+4nMAssay Description:Binding affinity to PRMT5 (unknown origin)/MEP50 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50303748((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataEC50:  16nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543445(CHEMBL4646904)
Affinity DataEC50:  56nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543446(CHEMBL4634826)
Affinity DataEC50:  12nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543447(CHEMBL4641267)
Affinity DataEC50:  90nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543448(CHEMBL4648777)
Affinity DataEC50:  620nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543449(CHEMBL4643667)
Affinity DataEC50:  220nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543450(CHEMBL4636476)
Affinity DataEC50:  240nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543451(CHEMBL4647445)
Affinity DataEC50:  50nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543452(CHEMBL4648344)
Affinity DataEC50:  66nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50543453(CHEMBL4649422)
Affinity DataEC50:  68nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50561818(CHEMBL4783377)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to N-terminal FLAG-tagged human PRMT5 (1 to 637 residues)/N-terminal thrombin His-tagged MEP50 (2 to 342 residues) expressed in bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50572990(CHEMBL4859105)
Affinity DataEC50:  3.00E+3nMAssay Description:Activity at human wild type PRMT5/HA-tagged WDR77 hetero octameric complex expressed in HEK293 (Expi293) cells assessed as PRMT5 adduct formation inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM22111((2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfa...)
Affinity DataKd:  661nMAssay Description:Inhibition of streptavidin sensor chip immobilized biotinylated human PRMT5/MEP50 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50585598(CHEMBL1235831)
Affinity DataKd:  550nMAssay Description:Inhibition of streptavidin sensor chip immobilized biotinylated human PRMT5/MEP50 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607687(CHEMBL5218659)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607688(CHEMBL5219345)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607689(CHEMBL5218923)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607690(CHEMBL5220982)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607691(CHEMBL5220153)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607692(CHEMBL5220599)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607693(CHEMBL5220557)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607694(CHEMBL5220853)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607695(CHEMBL5218466)
Affinity DataKd:  719nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607696(CHEMBL5219439)
Affinity DataKd:  1.29E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607697(CHEMBL5218911)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607697(CHEMBL5218911)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607698(CHEMBL5220001)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607699(CHEMBL5219742)
Affinity DataKd:  452nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607700(CHEMBL5220186)
Affinity DataKd:  352nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607700(CHEMBL5220186)
Affinity DataKd:  352nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607701(CHEMBL5219207)
Affinity DataKd:  562nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607702(CHEMBL5219972)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607703(CHEMBL5218498)
Affinity DataKd:  430nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607704(CHEMBL5219659)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607705(CHEMBL5219211)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607706(CHEMBL5219833)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607707(CHEMBL5219252)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607708(CHEMBL5218539)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607709(CHEMBL5219733)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607710(CHEMBL5219756)
Affinity DataKd:  905nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607711(CHEMBL5220143)
Affinity DataKd:  670nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607712(CHEMBL5221082)
Affinity DataKd:  654nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607713(CHEMBL5218559)
Affinity DataKd:  531nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607714(CHEMBL5220866)
Affinity DataKd:  447nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50607715(CHEMBL5218548)
Affinity DataKd:  412nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
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