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Report error Found 511 of affinity data for UniProtKB/TrEMBL: Q8R455
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083005(CHEMBL3422799)
Affinity DataEC50:  140nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082783(CHEMBL3422798)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082781(CHEMBL3422796)
Affinity DataEC50:  130nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082780(CHEMBL1451030)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50082778(CHEMBL3422794)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083006(CHEMBL3422800)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083008(CHEMBL3422802)
Affinity DataEC50:  1.54E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083012(CHEMBL3422806)
Affinity DataEC50:  890nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083013(CHEMBL3422807)
Affinity DataEC50:  620nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083014(CHEMBL3422808)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083015(CHEMBL3422809)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083016(CHEMBL3422810)
Affinity DataEC50:  600nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083017(CHEMBL3422811)
Affinity DataEC50:  300nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50083018(CHEMBL3422812)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50241426(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at rat recombinant TRPM8 receptor expressed in HEK293 cells assessed as increase in intracellular calcium concentration by fluorimet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  7.50E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2017
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50159506(CHEMBL3787319)
Affinity DataEC50:  4.00E+4nMAssay Description:Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2017
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50441018(CHEMBL67100)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as induction of intracellular calcium influx by Fluo-4-AM dye-based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420658(CHEMBL2087053)
Affinity DataEC50:  4.58E+4nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420659(CHEMBL2087075)
Affinity DataEC50:  4.34E+4nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50240432(5-methyl-2-(propan-2-yl)phenol | thymol | 1-hydrox...)
Affinity DataEC50:  5.22E+4nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420662(CHEMBL1385022)
Affinity DataEC50:  5.10E+3nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420691(CHEMBL2087061)
Affinity DataEC50:  4.80E+3nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420677(CHEMBL2087057)
Affinity DataEC50:  270nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420678(CHEMBL2087056)
Affinity DataEC50:  1.70E+3nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420679(CHEMBL2087055)
Affinity DataEC50:  850nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420681(CHEMBL2087052)
Affinity DataEC50:  600nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50420675(CHEMBL2087059)
Affinity DataEC50:  440nMAssay Description:Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50535861(CHEMBL4560497)
Affinity DataEC50:  2.08E+4nMAssay Description:Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50535884(CHEMBL4551621)
Affinity DataEC50:  1.42E+4nMAssay Description:Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50535885(CHEMBL4586770)
Affinity DataEC50:  1.59E+4nMAssay Description:Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50535896(CHEMBL4562665)
Affinity DataEC50:  2.61E+4nMAssay Description:Agonist activity at recombinant rat TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo-4-AM probe-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50465610(CHEMBL4295040)
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM248583(US9434711, 496)
Affinity DataIC50: 1.80nMT: 2°CAssay Description:For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50465611(CHEMBL4284808)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation at 0.2 uM by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 5nMT: 2°CAssay Description:For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50036517(CHEMBL3353597)
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50463853(CHEMBL4237618)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50036554(CHEMBL3353609)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50463854(CHEMBL4251427)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50463846(CHEMBL4243837)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50463863(CHEMBL4251467)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50442406(CHEMBL2443061)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at rat TRPM8 by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50008716(CHEMBL3235983)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior to icilin chall...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50317558(N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]biphe...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat TRMP8 receptor expressed in HEK293 cells assessed as menthol-induced calcium elevationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50365710(CHEMBL1955989)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat TRPM8 by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50463850(CHEMBL4241349)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
National Research Council

Curated by ChEMBL
LigandPNGBDBM50463855(CHEMBL4248077)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
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