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TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50573254(CHEMBL4872876)
Affinity DataKd:  110nMAssay Description:Binding affinity to human IL-17A assessed as dissociation constant in PBS-T measured after 60 mins by Biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50573255(CHEMBL4858175)
Affinity DataKd:  12nMAssay Description:Binding affinity to human IL-17A assessed as dissociation constant in PBS-T measured after 60 mins by Biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50573256(CHEMBL4854787)
Affinity DataKd:  89nMAssay Description:Binding affinity to human IL-17A assessed as dissociation constant in PBS-T measured after 60 mins by Biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50573257(CHEMBL4878993)
Affinity DataKd:  13nMAssay Description:Binding affinity to human IL-17A assessed as dissociation constant in PBS-T measured after 60 mins by Biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50573258(CHEMBL4869568)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to biotinylated human IL-17A by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50581141(CHEMBL5075374)
Affinity DataKd: <500nMAssay Description:Binding affinity to IL-17A (unknown origin) measured by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50581142(CHEMBL3785600)
Affinity DataKd: <500nMAssay Description:Binding affinity to IL-17A (unknown origin) measured by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50581143(CHEMBL5077648)
Affinity DataKd: <660nMAssay Description:Binding affinity to IL-17A (unknown origin) measured by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50581144(CHEMBL5087050)
Affinity DataKd: <141nMAssay Description:Binding affinity to IL-17A (unknown origin) measured by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50581145(CHEMBL5079201)
Affinity DataKd:  30nMAssay Description:Binding affinity to IL-17A (unknown origin) measured by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50581146(CHEMBL5069442)
Affinity DataKd:  73nMAssay Description:Binding affinity to IL-17A (unknown origin) measured by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50597429(CHEMBL5194116)
Affinity DataKd:  32nMAssay Description:Binding affinity to human IL-17A assessed as thermal stability by measuring increase in unfolding temperature by differential scanning fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50594562(CHEMBL5177049)
Affinity DataKd:  507nMAssay Description:Binding affinity at His tagged human IL-17A expressed in Escherichia coli BL21-(DE3) assessed as dissociation constant incubated for 30 mins by MST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50594562(CHEMBL5177049)
Affinity DataKd:  507nMAssay Description:Binding affinity at His tagged human IL-17A expressed in Escherichia coli BL21-(DE3) assessed as dissociation constant incubated for 30 mins by MST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50594562(CHEMBL5177049)
Affinity DataKd:  328nMAssay Description:Binding affinity at His tagged human IL-17A expressed in Escherichia coli BL21-(DE3) assessed as dissociation constant incubated for 30 mins by MST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50594562(CHEMBL5177049)
Affinity DataKd:  507nMAssay Description:Binding affinity at His tagged human IL-17A expressed in Escherichia coli BL21-(DE3) assessed as dissociation constant incubated for 30 mins by MST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50594563(CHEMBL5177000)
Affinity DataKd:  9.40E+4nMAssay Description:Binding affinity at His tagged human IL-17A expressed in Escherichia coli BL21-(DE3) assessed as dissociation constant incubated for 30 mins by MST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50594564(CHEMBL5200412)
Affinity DataKd:  5.11E+4nMAssay Description:Binding affinity at His tagged human IL-17A expressed in Escherichia coli BL21-(DE3) assessed as dissociation constant incubated for 30 mins by MST a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50581143(CHEMBL5077648)
Affinity DataKd:  660nMAssay Description:Binding affinity to biotinylated Bap-tagged human IL-17A assessed as dissociation constant by SPR binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50582230(CHEMBL5091495)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50578383(CHEMBL4870813)
Affinity DataIC50: 1nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50582227(CHEMBL5081660)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50582229(CHEMBL5080633)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50582232(CHEMBL5091603)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50582228(CHEMBL5077953)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50582231(CHEMBL5092697)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50578381(CHEMBL4860574)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50578382(CHEMBL4865978)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50578386(CHEMBL4872143)
Affinity DataIC50: 2nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50574356(CHEMBL4845695 | US12252491, Example 27)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50578384(CHEMBL4850368)
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50578385(CHEMBL4851738)
Affinity DataIC50: 3nMAssay Description:Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50574357(CHEMBL4855085 | US12252491, Example 28)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548167(WO2022091056, Example 158)
Affinity DataIC50: 6.10nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50574355(CHEMBL4874078 | US12252491, Example 26)
Affinity DataIC50: 7nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548005(2,4-dimethyl-3-(4-((S)-2-(1-methyl-1H-pyrazole-5-c...)
Affinity DataIC50: 8nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50581144(CHEMBL5087050)
Affinity DataIC50: 9nMAssay Description:Inhibition of IL-17A (unknown origin) measured by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50574352(CHEMBL4876088 | US12252491, Example 19)
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50574354(CHEMBL4866932 | US12252491, Example 21)
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548056(WO2022091056, Example 48)
Affinity DataIC50: 12nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548093(WO2022091056, Example 84)
Affinity DataIC50: 14nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548188(WO2022091056, Example 196 | WO2022091056, Example ...)
Affinity DataIC50: 14nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17A(Human)
Saitama University

Curated by ChEMBL
LigandPNGBDBM50574353(CHEMBL4860250 | US12252491, Example 20)
Affinity DataIC50: 14nMAssay Description:Inhibition of IL-17A in human HT-29 cells assessed as neutralization measured after 48 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548071(WO2022091056, Example 62)
Affinity DataIC50: 15nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548020(WO2022091056, Example 13a)
Affinity DataIC50: 16nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548061(WO2022091056, Example 53)
Affinity DataIC50: 16nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548006(4-chloro-3-(4-((S)-2-cyclohexyl-2-(1-methyl-1H-pyr...)
Affinity DataIC50: 17nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548046(WO2022091056, Example 38)
Affinity DataIC50: 17nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548055(WO2022091056, Example 47)
Affinity DataIC50: 17nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

TargetInterleukin-17 receptor A/(Human)
Novartis

WIPO
LigandPNGBDBM548054(WO2022091056, Example 46)
Affinity DataIC50: 18nMAssay Description: Dilutions of test compounds in DMSO are plated onto white low-volume 384-well plates (Greiner, #784075). Specifically, solutions of graded concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022091056

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