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TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50514507(CHEMBL1583158)
Affinity DataKd:  1.12E+3nMAssay Description:Binding affinity to human CHIT1 catalytic domain overexpressed in Pichia pastoris assessed by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50214361(CHEMBL415389)
Affinity DataIC50: 7.53nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM10854(4-[(1S,4R,10S,13S,16S,18R)-10-{3-[(acetamidomethan...)
Affinity DataIC50: 13nMpH: 5.2 T: 2°CAssay Description:The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2006
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50554342(CHEMBL4776610)
Affinity DataIC50: 14nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50554344(CHEMBL4756869)
Affinity DataIC50: 16nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50214358(CHEMBL318258)
Affinity DataIC50: 16.1nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50554343(CHEMBL4794014)
Affinity DataIC50: 18nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504025(CHEMBL4464754)
Affinity DataIC50: 21nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50554345(CHEMBL4789376)
Affinity DataIC50: 22nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50554347(CHEMBL4755139)
Affinity DataIC50: 22nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50554340(CHEMBL4788866)
Affinity DataIC50: 23nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50554346(CHEMBL4764430)
Affinity DataIC50: 23nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504017(CHEMBL4541831)
Affinity DataIC50: 27nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50554348(CHEMBL4749391)
Affinity DataIC50: 32nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50243685(CHEMBL4084573)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N"...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50214357(CHEMBL319102)
Affinity DataIC50: 41nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504019(CHEMBL4580568)
Affinity DataIC50: 41nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504019(CHEMBL4580568)
Affinity DataIC50: 41nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50214360(CHEMBL327266)
Affinity DataIC50: 41.1nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504028(CHEMBL4520755)
Affinity DataIC50: 44nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504037(CHEMBL4470253)
Affinity DataIC50: 44nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504016(CHEMBL4537828)
Affinity DataIC50: 47nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504024(CHEMBL4461925)
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504024(CHEMBL4461925)
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50541930(CHEMBL4637417)
Affinity DataIC50: 49nMAssay Description:Inhibition of full length recombinant C-terminal His-taged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504034(CHEMBL4588384)
Affinity DataIC50: 59nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50541931(CHEMBL4634943)
Affinity DataIC50: 79nMAssay Description:Inhibition of full length recombinant C-terminal His-taged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50214359(CHEMBL103401)
Affinity DataIC50: 80nMAssay Description:Compound was evaluated for inhibitory activity against Trichoderma ChitinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504039(CHEMBL4442663)
Affinity DataIC50: 82nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504031(CHEMBL4521547)
Affinity DataIC50: 84nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50504014(CHEMBL4547227)
Affinity DataIC50: 87nMAssay Description:Inhibition of full-length C-terminal his-tagged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50541933(CHEMBL4646309)
Affinity DataIC50: 90nMAssay Description:Inhibition of full length recombinant C-terminal His-taged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349911((S)-5-(4-(3-(4- chlorobenzyl)morpholino) piperidin...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349913((S)-5-(4-(3-(4-bromobenzyl)morpholino)piperidin-1-...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349914(5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholin...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349915(5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-ethylmorpholino...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349916(5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-isopropylmorpho...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349917(5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-isobutylmorphol...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349919((2R,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349920(5-(4-((2R,5S)-5-(4-chlorobenzyl)-2-(methoxymethyl)...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349921(5-(4-((2R,5S)-5-(4-chlorobenzyl)-2-(ethoxymethyl)m...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349922((2R,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349923(2-((2R,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)pip...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349924(5-(4-((2R,5S)-5-(4-chlorobenzyl)-2-(2-methoxypropa...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349925((R)-5-(2-(4-chlorobenzyl)-[1,4′-bipiperidin]...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349926(ethyl (6R)-1′-(5-amino-4H-1,2,4-triazol-3-yl...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349934((R)-5-(4-(2-(4-chlorobenzyl)pyrrolidin-1-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349956(5-(4-((2S,4S)-2-(4-chlorobenzyl)-4-methoxypyrrolid...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349957((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetChitotriosidase-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM349960((3R,5S)-1-(1-(5-amino-1H-1,2,4-triazol-3-yl)piperi...)
Affinity DataIC50: 100nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

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