Compile Data Set for Download or QSAR
Report error Found 429 of affinity data for UniProtKB/TrEMBL: Q05469
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147315(2-(4-(3-fluorophenyl)piperidine-1-carbonyl)-4-(2-m...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50142719(Morpholin-4-yl-carbamic acid 4-[(4-tert-butyl-cycl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant hormone sensitive lipase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147297(4-Isopropyl-2-[4-(3-methoxy-phenyl)-piperazine-1-c...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147299(4-butyl-3-methyl-2-(4-methylpiperidine-1-carbonyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147270(3-methyl-4-(2-phenoxyethyl)-2-(piperidine-1-carbon...)
Affinity DataIC50: 2nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147251(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147243(4-Isopropyl-3-methyl-2-(piperidine-1-carbonyl)-2H-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50233398(CHEMBL4063082)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human HSL expressed in baculovirus infected sf9 cells using PNPB as substrate after 5 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50233398(CHEMBL4063082)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human HSL expressed in baculovirus infected sf9 insect cells using PNPB as substrate after 5 mins by spectrophotometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2020
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM121019(US8722721, 11)
Affinity DataIC50: 2.40nMpH: 7.2 T: 2°CAssay Description:HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50138735((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50142713((3,4-Dihydro-1H-isoquinolin-2-yl)-carbamic acid 4-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant hormone sensitive lipase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147281(4-isobutyl-3-methyl-2-(4-methylpiperidine-1-carbon...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147257(4-(2-ethoxyethyl)-3-methyl-2-(4-methylpiperidine-1...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147251(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM121018(US8722721, 10)
Affinity DataIC50: 3.70nMpH: 7.2 T: 2°CAssay Description:HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147253(2-[4-(3-Fluoro-phenyl)-piperidine-1-carbonyl]-4-is...)
Affinity DataIC50: 4nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147279(N-(2-fluorobenzyl)-4-isopropyl-N,3-dimethyl-5-oxoi...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147245(4-isobutyl-3-methyl-2-(4-phenylpiperidine-1-carbon...)
Affinity DataIC50: 4nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147241(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147267(4-cyclohexyl-3-methyl-2-(4-methylpiperidine-1-carb...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147272(4-(2-methoxyethyl)-3-methyl-2-(4-m-tolylpiperidine...)
Affinity DataIC50: 4nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147270(3-methyl-4-(2-phenoxyethyl)-2-(piperidine-1-carbon...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147298(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50142731([4-(Morpholin-4-ylcarbamoyloxy)-phenyl]-acetic aci...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant hormone sensitive lipase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147248(4-(2-methoxyethyl)-3-methyl-2-(4-phenylpiperidine-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147303(4-Benzyl-3-methyl-2-(piperidine-1-carbonyl)-2H-iso...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147289(4-isobutyl-3-methyl-2-(piperidine-1-carbonyl)isoxa...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147260(N-benzyl-4-isopropyl-N,3-dimethyl-5-oxoisoxazole-2...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147244(1-(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carbo...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147276(4-Cyclopentyl-3-methyl-2-(piperidine-1-carbonyl)-2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147282(3-methyl-4-(phenylthio)-2-(piperidine-1-carbonyl)i...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147280(3-Methyl-2-(4-methyl-piperidine-1-carbonyl)-4-(tet...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147283(4-Isopropyl-3-methyl-2-(4-methyl-piperidine-1-carb...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147234(4-isopropyl-3-methyl-2-(1-phenylpiperazine-4-carbo...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147300(4-(4-chlorophenylthio)-3-methyl-2-(piperidine-1-ca...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147269(2-(3,3-Dimethyl-piperidine-1-carbonyl)-4-isopropyl...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147296(4-Butyl-3-methyl-2-(piperidine-1-carbonyl)-2H-isox...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50180627(CHEMBL3814077)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human HSL expressed in Sf9 insect cells using PNPB as substrate measured after 5 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147271(4-isopropyl-N,3-dimethyl-5-oxo-N-phenylisoxazole-2...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM120365(US8703807, 1)
Affinity DataIC50: 7.70nMpH: 7.2 T: 2°CAssay Description:HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147262(4-isopropyl-3-methyl-2-(thiomorpholine-4-carbonyl)...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147259(4-cyclopentyl-3-methyl-2-(4-phenylpiperidine-1-car...)
Affinity DataIC50: 8nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50233399(CHEMBL4101186)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human HSL expressed in baculovirus infected sf9 cells using PNPB as substrate after 5 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2019
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50260458(CHEMBL4063918)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human HSL expressed in baculovirus infected sf9 insect cells using PNPB as substrate after 5 mins by spectrophotometric ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2020
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147241(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Affinity DataIC50: 9nMAssay Description:Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50147263(N-cyclohexyl-4-isopropyl-N,3-dimethyl-5-oxoisoxazo...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant hormone sensitive lipase (HSL)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM97626(US8470841, 2)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2013
Entry Details
Go to US Patent

TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM97628(US8470843, 4)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2013
Entry Details
Go to US Patent

TargetHormone-sensitive lipase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM120375(US8703807, 11)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:HSL enzyme activity was measured by a colorimetric assay using 2,3-dimercapto-1-propanol tributyrate (Aldrich, St. Louis, Mo.) as a substrate. Typica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

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