Compile Data Set for Download or QSAR
Report error Found 41 of affinity data for UniProtKB/TrEMBL: Q01062
LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to PDE2A in rat striatal membranes after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2019
Entry Details Article
PubMed
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)
Affinity DataEC50:  670nMAssay Description:Inhibition of PDE2a in rat primary cortical neurons assessed as increase in Bay 41-8543-stimulated intracellular cGMP level preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50146545(2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibitory concentration against phosphodiesterase 2 from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50033306(Benzyl-(6-nitro-2-pyridin-3-yl-quinazolin-4-yl)-am...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50033312(Urapidil-5-methyl | CHEMBL539806 | Benzyl-(6-chlor...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50033293(Benzyl-(2-imidazol-1-yl-6-methoxy-quinazolin-4-yl)...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase 2 from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM15297(N-Cyclohexyl-N-methyl-4-(2-oxo-1,2-dihydro-quinoli...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase 2 from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14769(6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase 2 from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase 2 from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50421642(CHEMBL516604)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase 2 from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50033302(Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine | CH...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM86644(BC11-38-2 | US9173884, BC11-38-2)
Affinity DataIC50: 1.84E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50033284(CHEMBL119841 | cid_667555 | Benzyl-(2-pyridin-3-yl...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50033291(Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine | C...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50033296(Benzyl-(2-phenyl-quinazolin-4-yl)-amine | CHEMBL72...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50404744(CHEMBL19047)
Affinity DataIC50: 2.45E+4nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50033290(Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine | C...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM86643(BC11-38-1 | US9173884, BC11-38-1)
Affinity DataIC50: 4.00E+4nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50404740(CHEMBL436338)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50033287(Benzyl-(6-chloro-2-pyridin-3-yl-quinazolin-4-yl)-a...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50404743(CHEMBL273765)
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50404745(CHEMBL18262)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataIC50: 8.13E+4nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50404748(NSC-115922 | CHEMBL19032)
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50404739(CHEMBL276918)
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM86646(BC11-38-4 | US9173884, BC11-38-4)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
LigandPNGBDBM60808(BDBM86640 | US9173884, BC11-19)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
LigandPNGBDBM60812(BDBM86641 | US9173884, BC11-28)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
LigandPNGBDBM86642(BC11-38 | US9173884, BC11-38)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
LigandPNGBDBM86645(BC11-38-3 | US9173884, BC11-38-3)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
LigandPNGBDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
LigandPNGBDBM86639(BC11-15 | US9173884, BC11-15)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50404741(CHEMBL278972)
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50404746(NSC-115919 | PENTAACETYLQUERCETIN)
Affinity DataIC50: 2.75E+5nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50404742(CHEMBL18487)
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50404747(CHEMBL18415)
Affinity DataIC50: 7.00E+5nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50010981(4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one |...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50404738(CHEMBL18609)
Affinity DataIC50: 1.30E+6nMAssay Description:Inhibition of rat brain particulate cGMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataKi:  4.20nMAssay Description:Displacement of radiolabeled 4-(azetidin-1-yl)-3-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-1-(tritritiomethyl)pyrazolo[3,4-d]pyrimidine from PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed