Compile Data Set for Download or QSAR
Report error Found 137 of affinity data for UniProtKB/TrEMBL: P70596
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50169442((1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-c...)
Affinity DataEC50:  5.00E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in rat melanocortin receptor (rMC4R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50373476(CHEMBL255286)
Affinity DataEC50:  10nMAssay Description:Agonist activity at rat MC4R expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50119368((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  2.90nMAssay Description:Functional activity as concentration of the compound at 50% maximum cAMP accumulation in rat Melanocortin-4 receptor (rMC4R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019939(CHEMBL3287569)
Affinity DataEC50:  640nMAssay Description:Agonist activity at rat GPR40 in presence of 0.01% human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2017
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314764(trans-N-(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-di...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at rat MC4R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323441(2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at rat melanocortin 4 receptor expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50373487(CHEMBL254589)
Affinity DataEC50:  0.900nMAssay Description:Binding affinity to rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50373472(CHEMBL429854)
Affinity DataEC50:  0.5nMAssay Description:Binding affinity to rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50201670(CHEMBL3930086)
Affinity DataEC50:  2.00E+4nMAssay Description:Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  2.70E+4nMAssay Description:Agonist activity at GPR40 in rat RINm cells assessed as increase glucose-stimulated insulin secretion after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392656(US10301286, Example 4)
Affinity DataEC50:  1.30nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392657(US10301286, Example 5)
Affinity DataEC50:  26nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392658(US10301286, Example 9)
Affinity DataEC50:  2.60nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392659(US10301286, Example 11)
Affinity DataEC50:  21nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392660(US10301286, Example 76)
Affinity DataEC50:  1.70nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392661(US10301286, Example 87)
Affinity DataEC50:  21nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392662(US10301286, Example 88)
Affinity DataEC50:  11nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM392663(US10301286, Example 89)
Affinity DataEC50:  3.10nMAssay Description:Experiment Method(1) Construction of Rat MC4 Receptor-Expressing VectorA rat MC4 receptor gene (GenBank Accession No.: NM_013099.2) was introduced in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50204020(CHEMBL3927519)
Affinity DataEC50:  14nMAssay Description:Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50247166(CHEMBL4082711)
Affinity DataEC50:  30nMAssay Description:Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50247156(CHEMBL4101472)
Affinity DataEC50:  68nMAssay Description:Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50247162(CHEMBL4075819)
Affinity DataEC50:  95nMAssay Description:Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50247167(CHEMBL4097527)
Affinity DataEC50:  98nMAssay Description:Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50247165(CHEMBL4077366)
Affinity DataEC50:  562nMAssay Description:Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50247163(CHEMBL4059614)
Affinity DataEC50:  216nMAssay Description:Agonist activity at rat PK-tagged GPR40 expressed in human U2OS cells assessed as EA-tagged beta-arrestin recruitment after 90 mins in presence of 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2019
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50405276(CHEMBL4167323)
Affinity DataEC50:  14nMAssay Description:Agonist activity at rat GPR40More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50405293(CHEMBL4166892)
Affinity DataEC50:  28nMAssay Description:Agonist activity at rat GPR40More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50405440(CHEMBL4172828)
Affinity DataEC50:  25nMAssay Description:Agonist activity at rat GPR40More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367218(CHEMBL4159416)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367219(CHEMBL4165147)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367222(CHEMBL4162778)
Affinity DataEC50:  2.30nMAssay Description:Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367220(CHEMBL4168422)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at recombinant rat GPR40 expressed in CHOK1 cells assessed as increase in IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM294016(US10106553, Compound 48 | 1-(5-((4-((2S)-1-(1H-Tet...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293969(US10106553, Compound 1 | (2S)-5-(2-(4-((3-(2- Meth...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293987(US10106553, Compound 19 | 5-((2S)-2-(4-((2-Methyl-...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293971(US10106553, Compound 3 | 5-((2S)-2-(4-((2-Fluoro-3...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293970(US10106553, Compound 2 | 5-((2S)-2-(4-((2-Chloro-3...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM294003(US10106553, Compound 35 | 5-((2S)-2-(4-((2-Iodo-3-...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM294006(US10106553, Compound 38 | 5-((2S)-2-(4-((2-Cyano-3...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM294007(US10106553, Compound 39 | (2S)-5-(2-(4-((2- (Methy...)
Affinity DataEC50:  128nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM294037(US10106553, Compound 69 | (2S)-5-(2-(4-((7-Fluoro-...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM294035(US10106553, Compound 67 | (2S)-5-(2-(4-((7-Chloro-...)
Affinity DataEC50:  108nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM294036(US10106553, Compound 68 | (2S)-5-(2-(4-((7-Chloro-...)
Affinity DataEC50:  71nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293978(US10106553, Compound 10 | (2S)-5-(2-(4-((3-(3-(2- ...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293983(US10106553, Compound 15 | (2S)-5-(2-(4-((3-(5-(2- ...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293999(US10106553, Compound 31 | 3-(4-(5-((4-((2S)-1-(1H-...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293980(US10106553, Compound 12 | (2S)-3-((4-(5-((4-(1-(1H...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293981(US10106553, Compound 13 | (2S)-5-(2-(4-((3-(2- (Tr...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293979(US10106553, Compound 11 | (2S)-3-(5-((4-(1-(1H-Tet...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM293990(US10106553, Compound 22 | (2S)-5-(2-(4-((3-(1-Meth...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at rat GPR40 assessed as increase in intracellular calcium flux by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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