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TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50452383(CHEMBL4218339)
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataEC50:  130nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha6beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457445(CHEMBL4212818)
Affinity DataEC50:  2.29E+3nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha6beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50427613(CHEMBL2322935)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462443(CHEMBL4238315)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462444(CHEMBL4244129)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462446(CHEMBL4238634)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50462450(CHEMBL4238712)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at rat GFP-fused GABA-A alpha1/beta2/gamma2 receptor expressed in human tsA201 cells at -60 mV holding potential by whole-cell volta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482687(CHEMBL426916)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482692(CHEMBL390326)
Affinity DataIC50: 20nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238234(US9388210, 14a | US9388210, 6a)
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238243(US9388210, 16a)
Affinity DataIC50: 28nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482688(CHEMBL387958)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482694(CHEMBL229535)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50215531(2-chloro-alpha-[[(4-chlorophenyl)amino]methylene]-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482691(CHEMBL556727)
Affinity DataIC50: 45nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482690(CHEMBL229374)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238245(US9388210, 17a)
Affinity DataIC50: 53nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238238(US9388210, 15a | US9388210, 13a)
Affinity DataIC50: 56nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482696(CHEMBL229201)
Affinity DataIC50: 79nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238234(US9388210, 14a | US9388210, 6a)
Affinity DataIC50: 128nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta2delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482686(CHEMBL227018)
Affinity DataIC50: 158nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457444(CHEMBL4213793)
Affinity DataIC50: 270nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta2delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482689(CHEMBL388639)
Affinity DataIC50: 398nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238238(US9388210, 15a | US9388210, 13a)
Affinity DataIC50: 474nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238235(US9388210, 14b | US9388210, 6b)
Affinity DataIC50: 501nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238244(US9388210, 16b)
Affinity DataIC50: 544nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238246(US9388210, 17b)
Affinity DataIC50: 605nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238236(US9388210, 6c)
Affinity DataIC50: 629nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataIC50: 630nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457444(CHEMBL4213793)
Affinity DataIC50: 740nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238248(US9388210, 5b)
Affinity DataIC50: 770nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238247(US9388210, 5a)
Affinity DataIC50: 997nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238249(US9388210, 5c)
Affinity DataIC50: 1.02E+3nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataIC50: 1.13E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta2gamma2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238239(US9388210, 15b | US9388210, 13b)
Affinity DataIC50: 1.20E+3nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482695(CHEMBL227017)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238237(US9388210, 6d)
Affinity DataIC50: 1.84E+3nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238235(US9388210, 14b | US9388210, 6b)
Affinity DataIC50: 2.03E+3nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457438(CHEMBL4208971)
Affinity DataIC50: 2.43E+3nMAssay Description:Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta2delta expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50482693(CHEMBL388638)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of rat GABA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM238239(US9388210, 15b | US9388210, 13b)
Affinity DataIC50: 9.60E+3nMpH: 7.4 T: 2°CAssay Description:Briefly, aliquots of membrane solution (0.5 mg/mL final protein concentration in assay) were incubated with 5 μM GABA, 2 nM [35S]TBPS (45−...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM26263(ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity for rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
LigandPNGBDBM26263(ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricycl...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity for rat GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50035527(3-Methyl-9H-beta-carboline | CHEMBL344859)
Affinity DataKi:  0.800nMAssay Description:Binding affinity for rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50165326(8-Chloro-2-phenyl-5H-3,3a,5,9b-tetraaza-cyclopenta...)
Affinity DataKi:  1.74nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50165329(8-Chloro-2-(4-methoxy-phenyl)-5H-3,3a,5,9b-tetraaz...)
Affinity DataKi:  1.82nMAssay Description:Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50001478(9H-beta-Carboline-3-carboxylic acid methyl ester |...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for mutant rat GABA-A receptor alpha-1-(arg)-beta-2-gamma-2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-2/gamma-2(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  2.10nMAssay Description:Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gamma2 subunits expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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