Compile Data Set for Download or QSAR
Report error Found 288 for UniProtKB: P47811
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14838(CHEMBL105248 | BIRB-796 Analog 32 | 1-(5-iso-Propy...)
Affinity DataKd:  6nMpH: 7.0 T: 2°CAssay Description:The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM13336(4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]...)
Affinity DataKd:  20nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14834(3-[3-(1-hydroxy-2-methylpropan-2-yl)-1-(4-methylph...)
Affinity DataKd:  56nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14842(1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}-3-...)
Affinity DataKd:  2.40E+3nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14838(CHEMBL105248 | BIRB-796 Analog 32 | 1-(5-iso-Propy...)
Affinity DataKd:  3.40nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14839(BIRB-796 Analog 33 | 3-(3-tert-butyl-1-phenyl-1H-p...)
Affinity DataKd:  0.230nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14843(3-[3-(1-methylcyclohexyl)-1-phenyl-1H-pyrazol-5-yl...)
Affinity DataKd:  1.90nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd:  0.0460nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14844(3-[3-tert-butyl-1-(6-methylpyridin-3-yl)-1H-pyrazo...)
Affinity DataKd:  0.180nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14845(3-(1-benzyl-3-tert-butyl-1H-pyrazol-5-yl)-1-{4-[2-...)
Affinity DataKd:  64nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14835(3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-{4-[2-...)
Affinity DataKd:  26nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14846(3-(3-tert-butyl-1-cyclohexyl-1H-pyrazol-5-yl)-1-{4...)
Affinity DataKd:  23nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14847(3-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataKd:  0.230nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14848(N-(3-{3-tert-butyl-5-[({4-[2-(morpholin-4-yl)ethox...)
Affinity DataKd:  9.90nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14849(3-[1-(4-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]...)
Affinity DataKd:  0.160nMpH: 7.0 T: 2°CAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14850(N-(4-{3-tert-butyl-5-[({4-[2-(morpholin-4-yl)ethox...)
Affinity DataKd:  64nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14851(3-[3-tert-butyl-1-(6-methoxypyridin-3-yl)-1H-pyraz...)
Affinity DataKd:  0.870nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14837(BIRB-796 Analog 4 | 3-[3-tert-butyl-1-(4-methylphe...)
Affinity DataKd:  11nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14853(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  0.400nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14840(BIRB-796 Analog 30 | 3-[3-tert-butyl-1-(4-methylph...)
Affinity DataKd:  0.100nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14855(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  14nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14856(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  12nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14857(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{4-[2...)
Affinity DataKd:  1.5nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14858(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  0.0960nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14859(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  5.90nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14860(1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2...)
Affinity DataKd:  0.520nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14861(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Affinity DataKd:  3.5nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM14862(1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2...)
Affinity DataKd:  0.0740nMAssay Description:UV thermal melt experiments were carried out in a quartz cuvette loaded with sample containing enzyme and each test compound using a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM176672(US9115122, 76)
Affinity DataKd:  7.00E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM176674(US9115122, 76.3)
Affinity DataKd:  4.50E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM176677(US9115122, SF-2-062)
Affinity DataKd:  4.20E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM176678(US9115122, SF-2-054)
Affinity DataKd:  1.20E+4nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM176679(US9115122, SS-1-019)
Affinity DataKd:  8.30E+3nMAssay Description:CADD and biological testing to identify compounds that interact with novel ERK substrate docking sites. The known ERK2 docking sites include the DRS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50541795(CHEMBL4634665)
Affinity DataKd:  2.51E+4nMAssay Description:Binding affinity to 6x-His tagged mouse recombinant p38alpha expressed in Escherichia coli Rosetta 2 (Novagen) cells by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50541796(CHEMBL4634169)
Affinity DataKd:  5.78E+4nMAssay Description:Binding affinity to 6x-His tagged mouse recombinant p38alpha expressed in Escherichia coli Rosetta 2 (Novagen) cells by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50541797(CHEMBL4646170)
Affinity DataKd:  1.12E+5nMAssay Description:Binding affinity to 6x-His tagged mouse recombinant p38alpha expressed in Escherichia coli Rosetta 2 (Novagen) cells by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14 [G110A](Mouse)
Merck Research Laboratories

LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50: 0.100nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50: 0.130nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14 [G110D](Mouse)
Merck Research Laboratories

LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50: 0.140nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM17060(CHEMBL319556 | 1-(2,6-dichlorophenyl)-5-(2,4-diflu...)
Affinity DataIC50: 0.200nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM17061(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-[1...)
Affinity DataIC50: 0.200nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50421140(CHEMBL2088591)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM17074(5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-{4-[2-...)
Affinity DataIC50: 0.5nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM17081(5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-({8-me...)
Affinity DataIC50: 0.5nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50421137(CHEMBL2088588)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50421141(CHEMBL2088578)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM17082(5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-{[1-(p...)
Affinity DataIC50: 0.600nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50175995(N-(2,4-difluorophenyl)-3-(5-(3-(dimethylamino)prop...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against murine p38-alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM50194461(7-amino-5-(2,4-difluorophenyl)-1-(2,6-difluorophen...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of mouse p38alpha after 3 hrs by SPA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Mouse)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM17083(5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-[(2,2,...)
Affinity DataIC50: 0.700nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2007
Entry Details Article
PubMed
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