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TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126763((S)-2-amino-3-(3-hydroxy-5-tert-butyl-4-isoxazolyl...)
Affinity DataEC50:  2.20E+4nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor AMPA 1 (GluR1o)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126761(2-Amino-3-(5-tert-butyl-3-hydroxy-isothiazol-4-yl)...)
Affinity DataEC50:  5.20E+3nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor AMPA 1 (GluR1o)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  4.50E+3nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor AMPA 1 (GluR1o)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50048386(1-(4-aminophenyl)-3-methylcarbamyl-4-methyl-3,4-di...)
Affinity DataEC50:  2.80E+4nMAssay Description:Activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on glutamate/trichlorom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataEC50:  7.51E+3nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataEC50:  7.30E+4nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataEC50:  6.00E+4nMAssay Description:Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50316376(CHEMBL602962 | (S)-2-amino-3-(3-carboxy-5-methyl-4...)
Affinity DataEC50:  270nMAssay Description:Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244(CHEMBL73698 | 2-Amino-3-(4-bromo-3-hydroxy-isoxazo...)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50128264((R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)p...)
Affinity DataEC50:  4.70E+3nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataEC50:  382nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50316377((R,S)-6-(2-amino-2-carboxyethyl)-3-hydroxypyridazi...)
Affinity DataEC50:  258nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on 10 uM glutamate-indu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on 10 uM glutamate-indu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  1.98E+4nMAssay Description:Activity at human recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50316375(N-[2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfo...)
Affinity DataEC50:  5.65E+3nMAssay Description:Activity at human recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244(CHEMBL73698 | 2-Amino-3-(4-bromo-3-hydroxy-isoxazo...)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at recombinant GluA1 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50128264((R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)p...)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at GluA1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataEC50:  380nMAssay Description:Agonist activity at recombinant GluA1 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50316377((R,S)-6-(2-amino-2-carboxyethyl)-3-hydroxypyridazi...)
Affinity DataEC50:  260nMAssay Description:Agonist activity at recombinant GluA1 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  2.20E+4nMAssay Description:Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  2.26E+3nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50330411(1,2,3,7,8,11a-Hexahydro-6,9,11-trioxa-3a-aza-cyclo...)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50330417(N,N'-(octane-1,8-diyl)dipropane-2-sulfonamide | CH...)
Affinity DataEC50:  910nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50330418(N,N'-(heptane-1,7-diyl)dipropane-2-sulfonamide | C...)
Affinity DataEC50:  2.88E+3nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50330419(N,N'-(nonane-1,9-diyl)dipropane-2-sulfonamide | CH...)
Affinity DataEC50:  660nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50094024(propane-2-sulfonic acid [2-(4'-cyano-biphenyl-4-yl...)
Affinity DataEC50:  5.65E+3nMAssay Description:Inhibition of GluR1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50166285((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Affinity DataEC50:  4.80E+5nMAssay Description:Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50166286((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Affinity DataEC50:  4.20E+4nMAssay Description:Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  7.10E+4nMAssay Description:Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50059674((RS)-2-amino-3-[3-hydroxy-5-(1-methyl-2H-5-tetrazo...)
Affinity DataEC50: >3.00E+6nMAssay Description:Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50211399((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Affinity DataEC50:  3.00E+6nMAssay Description:Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50166287((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Affinity DataEC50:  5.50E+5nMAssay Description:Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50126761(2-Amino-3-(5-tert-butyl-3-hydroxy-isothiazol-4-yl)...)
Affinity DataEC50:  5.20E+3nMAssay Description:Agonist activity at GluA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataEC50: >3.00E+5nMAssay Description:Agonist activity at GluA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50252920((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Affinity DataEC50:  1.85E+4nMAssay Description:Agonist activity at cyclothiazide-desensitized human flip iGluR1 expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50252922((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Affinity DataEC50:  4.10E+3nMAssay Description:Agonist activity at cyclothiazide-desensitized human flip iGluR1 expressed in CHO-K1 cells by whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50512943(CHEMBL4448290)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at GluA1 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  3.30E+4nMAssay Description:Agonist activity at GluA1 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50512946(CHEMBL4451018)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at GluA1 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  3.31E+4nMAssay Description:Agonist activity at GluA1 receptor (unknown origin) expressed in HEK293 cells assessed induction of S-glutamate-induced calcium flux measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM426302(US10513523, Example 242 | 6-(7-Morpholino-2-phenyl...)
Affinity DataIC50: 0.0500nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM426136(US10513523, Example 75 | 5-[8-(4-Fluoro-1-piperidy...)
Affinity DataIC50: 0.0600nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM426170(US10513523, Example 109 | 5-(2-(4-Fluorophenyl)-8-...)
Affinity DataIC50: 0.0600nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM426273(US10513523, Example 213 | 6-[7-(4-Methoxy-1-piperi...)
Affinity DataIC50: 0.0600nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM426135(US10513523, Example 74 | 5-[2-(4-Fluorophenyl)-8-(...)
Affinity DataIC50: 0.0800nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM426234(US10513523, Example 174 | 5-[2-(4-Fluorophenyl)-7-...)
Affinity DataIC50: 0.0800nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM426272(US10513523, Example 212 | 4-[3-(1H-Indazol-5-yl)-4...)
Affinity DataIC50: 0.0800nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

TargetGlutamate receptor 1(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM426129(US10513523, Example 68 | 5-[2-(4-Fluorophenyl)-8-(...)
Affinity DataIC50: 0.100nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2020
Entry Details
Go to US Patent

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