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TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50077251((2S)-2-amino-5-{[(1Z)-hydrazino(methylthio)methyle...)
Affinity DataEC50:  1.80E+5nMAssay Description:Effective concentration against NADPH oxidase activity of iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50077250((2S)-2-amino-5-{[(1Z)-(hydroxyamino)(methylthio)me...)
Affinity DataEC50:  6.60E+3nMAssay Description:Effective concentration against NADPH oxidase activity of iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50077252((2S)-2-amino-5-[(hydrazinocarbonothioyl)amino]pent...)
Affinity DataEC50:  1.90E+5nMAssay Description:Effective concentration against NADPH oxidase activity of iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM29241(quinolinone, 12)
Affinity DataEC50:  120nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348735(CHEMBL1801474)
Affinity DataEC50:  1.03E+4nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348738(CHEMBL1801482)
Affinity DataEC50:  4.40E+3nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348741(CHEMBL1801487)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348721(CHEMBL1801490)
Affinity DataEC50:  3.10E+3nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348728(CHEMBL1801502)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348732(CHEMBL1801504)
Affinity DataEC50:  430nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348710(CHEMBL1801506)
Affinity DataEC50:  440nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348733(CHEMBL1801060)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50348709(CHEMBL1801062)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of mouse iNOS expressed in HEK293 cells assessed as inhibition of nitric oxide production after 18 hrs using 2,3-diaminonaphthalene by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50096347(CHEMBL224752)
Affinity DataIC50: 1nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138191(ONO-1714 | (1S,5S,6R,7R)-7-Chloro-5-methyl-2-aza-b...)
Affinity DataIC50: 3nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50363262(CHEMBL1944717)
Affinity DataIC50: 5nMAssay Description:Inhibition of mouse iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50386178(ONO-1714 | CHEMBL1800346)
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse recombinant iNOS activity assessed as conversion of [14C]-L-arginine to [14C]-L-citrulline by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50096337(CHEMBL3577126)
Affinity DataIC50: 16nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50096335(CHEMBL2064456)
Affinity DataIC50: 18nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50116666(CHEMBL76342 | CHEMBL75304 | 4-Methyl-3,6-dihydro-1...)
Affinity DataIC50: 22nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50096348(2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...)
Affinity DataIC50: 23nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50116674(6-Allyl-4-methyl-5,6-dihydro-1H-pyridin-(2Z)-ylide...)
Affinity DataIC50: 25nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50096338(CHEMBL3577127)
Affinity DataIC50: 29nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50115777(3-(3-Ethoxy-4,5-dimethoxy-phenyl)-1-(4-fluoro-phen...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration required to produce 50% inhibition of the response was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138189((4S,5R)-5-Methyl-4-propyl-oxazolidin-(2Z)-ylidenea...)
Affinity DataIC50: 41nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50350681(CHEMBL1813771)
Affinity DataIC50: 50nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138195((4S,5S)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine |...)
Affinity DataIC50: 56nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50401339(CHEMBL4161447)
Affinity DataIC50: 58nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138201(5-Methyl-oxazolidin-(2Z)-ylideneamine | CHEMBL1074...)
Affinity DataIC50: 74nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50350680(CHEMBL1813770)
Affinity DataIC50: 90nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50116667(4,5,5-Trimethyl-5,6-dihydro-1H-pyridin-(2Z)-yliden...)
Affinity DataIC50: 100nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50116668(4-Methyl-6-propyl-5,6-dihydro-1H-pyridin-(2Z)-ylid...)
Affinity DataIC50: 100nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50095303(CHEMBL3589092)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50226527(N-[3-(aminomethyl)benzyl]ethanimidamide | N-(3-Ami...)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50350683(CHEMBL1813764)
Affinity DataIC50: 100nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50226527(N-[3-(aminomethyl)benzyl]ethanimidamide | N-(3-Ami...)
Affinity DataIC50: 101nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138190((4S,5S)-5-Methyl-4-propyl-oxazolidin-(2Z)-ylidenea...)
Affinity DataIC50: 120nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138192((4S,5R)-4-Ethyl-5-methyl-oxazolidin-(2Z)-ylideneam...)
Affinity DataIC50: 120nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138194((4S,5S)-5-Ethyl-4-methyl-oxazolidin-(2Z)-ylideneam...)
Affinity DataIC50: 120nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50350684(CHEMBL1813769)
Affinity DataIC50: 120nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as conversion of L-citrulline to L-arginine incubated for 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138198((4S,5R)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine |...)
Affinity DataIC50: 130nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138184((4S,5R)-4,5-Dimethyl-oxazolidin-(2Z)-ylideneamine ...)
Affinity DataIC50: 150nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138185((4S,5R)-5-Ethyl-4-methyl-oxazolidin-(2Z)-ylideneam...)
Affinity DataIC50: 160nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50096339(CHEMBL3577128)
Affinity DataIC50: 160nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50095302(CHEMBL3589091)
Affinity DataIC50: 165nMAssay Description:Inhibition of mouse recombinant iNOS using [3H]L-arginine substrate assessed as formation of [3H]L-citruline by liquid scintillation counting analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50138187((4S,5S)-4-Ethyl-5-methyl-oxazolidin-(2Z)-ylideneam...)
Affinity DataIC50: 170nMAssay Description:Inhibition of inducible nitric oxide synthase (iNOS) in miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50403157(CHEMBL4171271)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50096340(CHEMBL3577129)
Affinity DataIC50: 200nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50292744(1-(Benzylamino)ethaniminium bromide | CHEMBL462334)
Affinity DataIC50: 200nMAssay Description:Inhibition of mouse macrophage iNOS assessed as nitric oxide mediated oxidation of oxyhemoglobin to methemoglobinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Mouse)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50096336(CHEMBL3577125)
Affinity DataIC50: 210nMAssay Description:Inhibition of iNOS in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of nitric oxide production after 48 hrs by Griess assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details Article
PubMed
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