Compile Data Set for Download or QSAR
Report error Found 15 for UniProtKB: P27914
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33252(phthalazine-based compound, 3)
Affinity DataIC50: 1.10E+3nM Kd:  7.70E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33256(phthalazine-based compound, 7)
Affinity DataIC50: 1.60E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33251(phthalazine-based compound, 2)
Affinity DataIC50: 2.30E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50: 5.80E+3nM Kd:  1.86E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33250(phthalazine-based compound, 1)
Affinity DataIC50: 6.00E+3nM Kd:  7.20E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33259(Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877 | Bz-NKRR-H)
Affinity DataIC50: 8.90E+3nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33257(phthalazine-based compound, 8)
Affinity DataIC50: 1.02E+4nM Kd:  1.63E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33253(phthalazine-based compound, 4)
Affinity DataIC50: 2.74E+4nM Kd:  2.29E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33255(phthalazine-based compound, 6)
Affinity DataIC50: 5.50E+4nM Kd:  5.40E+4nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33258(phthalazine-based compound, 9)
Affinity DataIC50: 1.00E+5nM Kd:  1.00E+5nMpH: 7.5 T: 2°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33265(guanidine, 5)
Affinity DataKi:  1.40E+4nM ΔG°:  -27.5kJ/molepH: 8.5 T: 2°CAssay Description:All proteases were assayed by monitoring the cleavage of peptide substrate with fluorescent reporter at room temperature with a microtiter plate spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33264(guanidine, 4)
Affinity DataKi:  2.30E+4nM ΔG°:  -26.3kJ/molepH: 8.5 T: 2°CAssay Description:All proteases were assayed by monitoring the cleavage of peptide substrate with fluorescent reporter at room temperature with a microtiter plate spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33261(biguanidine, 1)
Affinity DataKi:  4.40E+4nM ΔG°:  -24.7kJ/molepH: 8.5 T: 2°CAssay Description:All proteases were assayed by monitoring the cleavage of peptide substrate with fluorescent reporter at room temperature with a microtiter plate spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33260(biguanidine, 2)
Affinity DataKi:  4.23E+5nM ΔG°:  -19.1kJ/molepH: 8.5 T: 2°CAssay Description:All proteases were assayed by monitoring the cleavage of peptide substrate with fluorescent reporter at room temperature with a microtiter plate spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33262(biguanidine, 3)
Affinity DataKi:  1.78E+6nM ΔG°:  -15.6kJ/molepH: 8.5 T: 2°CAssay Description:All proteases were assayed by monitoring the cleavage of peptide substrate with fluorescent reporter at room temperature with a microtiter plate spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed