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TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  53nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  4.94E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018507(CHEMBL3290657)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50006222(CHEMBL8771 | (neplanocinA)5-(6-Amino-purin-9-yl)-3...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50006218((1R,2S,3R)-3-(6-amino-9H-purin-9-yl)cyclopentane-1...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018501(CHEMBL3290650)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018508(CHEMBL3290658)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018533(CHEMBL3290668)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050862(CHEMBL3322562)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050862(CHEMBL3322562)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50006222(CHEMBL8771 | (neplanocinA)5-(6-Amino-purin-9-yl)-3...)
Affinity DataIC50: 7.20nMAssay Description:Tested for inhibitory concentration against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50405728(CHEMBL2115462)
Affinity DataIC50: 8nMAssay Description:Inhibition of S-adenosyl-homocysteine (AdoHcy)hydrolase from rabbit erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50105901(CHEMBL3597832)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018514(CHEMBL3290663)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50006222(CHEMBL8771 | (neplanocinA)5-(6-Amino-purin-9-yl)-3...)
Affinity DataIC50: 10nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050877(CHEMBL3322547)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050877(CHEMBL3322547)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50006222(CHEMBL8771 | (neplanocinA)5-(6-Amino-purin-9-yl)-3...)
Affinity DataIC50: 15.2nMAssay Description:Inhibitory effect against S-adenosyl-L-homocysteine hydrolase of rabbit erythrocyte.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50006222(CHEMBL8771 | (neplanocinA)5-(6-Amino-purin-9-yl)-3...)
Affinity DataIC50: 15.2nMAssay Description:Inhibitory activity against S-adenosyl-L-homocysteine hydrolase from rabbit erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018508(CHEMBL3290658)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50281613(3-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-5-hydroxyme...)
Affinity DataIC50: 18nMAssay Description:Tested for inhibitory concentration against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018514(CHEMBL3290663)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018529(CHEMBL3290665)
Affinity DataIC50: 28nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50281612(5-(4-Amino-imidazo[4,5-c]pyridin-1-yl)-3-hydroxyme...)
Affinity DataIC50: 31nMAssay Description:Tested for inhibitory concentration against S-adenosyl-homocysteine hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018509(CHEMBL3290659)
Affinity DataIC50: 36nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018507(CHEMBL3290657)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50029130(Adenosine dialdehyde | CHEMBL165876)
Affinity DataIC50: 40nMAssay Description:Inhibition of S-adenosyl-homocysteine (AdoHcy)hydrolase from rabbit erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018512(CHEMBL3290662)
Affinity DataIC50: 41nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050874(CHEMBL3322550)
Affinity DataIC50: 44nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050874(CHEMBL3322550)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050868(CHEMBL3322556)
Affinity DataIC50: 49nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050875(CHEMBL3322549)
Affinity DataIC50: 49nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050875(CHEMBL3322549)
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50105907(CHEMBL3597818)
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050884(CHEMBL3322540)
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050884(CHEMBL3322540)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50006218((1R,2S,3R)-3-(6-amino-9H-purin-9-yl)cyclopentane-1...)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant human AHCY using SAH as substrate assessed as formation of homocysteine after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050869(CHEMBL3322555)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50105908(CHEMBL3597817)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050870(CHEMBL3322554)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50105899(CHEMBL3597816)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50019042(CHEMBL53931 | 3-(6-Amino-purin-9-yl)-5-hydroxymeth...)
Affinity DataIC50: 80nMAssay Description:Inhibition of S-adenosyl-homocysteine (AdoHcy)hydrolase from rabbit erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050883(CHEMBL3322541)
Affinity DataIC50: 81nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050883(CHEMBL3322541)
Affinity DataIC50: 81nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50018505(CHEMBL3290655)
Affinity DataIC50: 98nMAssay Description:Inhibition of AHCY in human SH-SY5Y cells assessed as formation of homocysteine after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050865(CHEMBL3322559)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50105904(CHEMBL3597821)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050871(CHEMBL3322553)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050871(CHEMBL3322553)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human S-adenosyl-L-homocysteine hydrolase assessed as hydrolysis of AdoHcy after 8 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2016
Entry Details Article
PubMed
TargetAdenosylhomocysteinase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50050863(CHEMBL3322561)
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant S-adenosyl-L-homocysteine hydrolase assessed as AdoHcy hydrolysis activity by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
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