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TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50262041(5-(((5-carboxy-2-methylfuran-3-yl)methylthio)methy...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50431467(CHEMBL2348305)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50262039(3-amino-2-(benzylideneamino)-5-mercaptophenol | CH...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509110(CHEMBL4458668)
Affinity DataIC50: 5.00E+3nMAssay Description:Competitive inhibition of human DNA ligase 1 using nicked DNA as substrate by high-throughput fluorescence energy transfer-based DNA joining assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50261995(N'-(2-hydroxy-5-nitrobenzylidene)-2-(3,5-dibromo-4...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50262038(CHEMBL467373 | cid_3420390 | 3-(4-Bromo-benzenesul...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50261993(5-(methylthio)thiophene-2-carboxylic acid | CHEMBL...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509109(CHEMBL4461698)
Affinity DataIC50: 1.00E+4nMAssay Description:Competitive inhibition of human DNA ligase 1 using nicked DNA as substrate by high-throughput fluorescence energy transfer-based DNA joining assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50262037(5-(2-(4-hydroxy-3-nitrobenzylidene)hydrazinyl)-4-c...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509111(CHEMBL4468667)
Affinity DataIC50: 1.20E+4nMAssay Description:Uncompetitive inhibition of human DNA ligase 1 using nicked DNA as substrate by high-throughput fluorescence energy transfer-based DNA joining assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50261994(2-(7-chloro-4-nitrobenzo[c][1,2,5]oxadiazol-5-ylth...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509117(CHEMBL4554752)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of human DNA ligase 1 expressed in Escherichia coli BL21 (DE3) cells using nicked DNA as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509114(CHEMBL4453581)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of human DNA ligase 1 expressed in Escherichia coli BL21 (DE3) cells using nicked DNA as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509115(CHEMBL4556388)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of human DNA ligase 1 expressed in Escherichia coli BL21 (DE3) cells using nicked DNA as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509119(CHEMBL4532660)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of human DNA ligase 1 expressed in Escherichia coli BL21 (DE3) cells using nicked DNA as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509108(CHEMBL4440472)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of human DNA ligase 1 expressed in Escherichia coli BL21 (DE3) cells using nicked DNA as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509118(CHEMBL4577708)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509116((+/-)-Protolichesterinic acid)
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509120(CHEMBL4464745)
Affinity DataIC50: 2.11E+4nMAssay Description:Inhibition of human DNA ligase 1 expressed in Escherichia coli BL21 (DE3) cells using nicked DNA as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509112(CHEMBL4456837)
Affinity DataIC50: 2.31E+4nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50262042((2-hydroxyphenyl)(4-hydroxyphenyl)methanone | CHEM...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50262040(7-(4-methoxyphenyl)pteridine-2,4-diol | CHEMBL5112...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human recombinant DNA ligase 1 by radioactive gel-based ligation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50478514(Fagaronine | Fagaronine Chloride)
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509113(CHEMBL4465196)
Affinity DataIC50: 2.65E+4nMAssay Description:Inhibition of human DNA ligase 1 expressed in Escherichia coli BL21 (DE3) cells using nicked DNA as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509122(CHEMBL4541795)
Affinity DataIC50: 3.64E+4nMAssay Description:Inhibition of human DNA ligase 1 expressed in Escherichia coli BL21 (DE3) cells using nicked DNA as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383695(CHEMBL2030372)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383696(CHEMBL2030374)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383697(CHEMBL2030350)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383698(CHEMBL2030355)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383699(CHEMBL2030365)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383700(CHEMBL2030366)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383701(CHEMBL2030367)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383702(CHEMBL2030368)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383703(CHEMBL2030369)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383704(CHEMBL2030370)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383705(CHEMBL2030371)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383706(CHEMBL2030373)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383707(CHEMBL2030354)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383708(CHEMBL2030351)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383709(CHEMBL2030352)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50383710(CHEMBL2030353)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human ATP-dependent DNA ligase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50017566(CHEBI:7578 | NITIDINE)
Affinity DataIC50: 7.17E+4nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataIC50: 8.79E+4nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM22982(Glycosyl Ureides, 3b | ethyl 3-[(3aS,6R,6aS)-6-(be...)
Affinity DataIC50: 1.27E+5nMpH: 8.0 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50346601(Oleanolic acid (OA)(Compound 1) | NSC-114945 | OLE...)
Affinity DataIC50: 1.86E+5nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50509121(CHEMBL4586295)
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50335293((2R,3R,4S,5R)-2-(6-amino-2-(butylthio)-9H-purin-9-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human DNA Ligase I by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50478515(CHEBI:73107 | Aleuritolic Acid | Maprounic Acid)
Affinity DataIC50: 2.08E+5nMAssay Description:Inhibition of human DNA ligase 1 using 52-mer DNA/25-mer DNA/27-mer DNA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA ligase 1(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM22986(18-[6-(piperidin-1-yl)hexyl]-8-thia-18-azatetracyc...)
Affinity DataIC50: 2.12E+5nMpH: 8.0 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2008
Entry Details Article
PubMed
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