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LigandPNGBDBM50017294(CHEMBL3288029)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of rat PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50017295(CHEMBL3288030)
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of rat PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50450772(CHEMBL322092)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2014
Entry Details Article
PubMed
LigandPNGBDBM50450771(CHEMBL326655)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2014
Entry Details Article
PubMed
LigandPNGBDBM50450770(CHEMBL320307)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2014
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50218545(Nitraquazone)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50072197(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Affinity DataIC50: 15nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072197(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Affinity DataIC50: 25nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50072195(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Affinity DataIC50: 43nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085138(4-[8-(3-Chloro-phenyl)-[1,7]naphthyridin-6-yl]-ben...)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085135(4-(8-(3-nitrophenyl)-1,7-naphthyridin-6-yl)benzoic...)
Affinity DataIC50: 49nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50072194(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Affinity DataIC50: 50nMAssay Description:Inhibition of [3H]-rolipram binding to membrane-bound PDE4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072195(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Affinity DataIC50: 70nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072211(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 80nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085146(8-(3-Nitro-phenyl)-6-pyridin-3-yl-[1,7]naphthyridi...)
Affinity DataIC50: 81nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085139(4-[8-(3-Cyano-phenyl)-[1,7]naphthyridin-6-yl]-benz...)
Affinity DataIC50: 85nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072199(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Affinity DataIC50: 110nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085136(8-(3-Nitro-phenyl)-6-phenyl-[1,7]naphthyridine | C...)
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50072200(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 145nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085140(6-Allyl-8-(3-nitro-phenyl)-[1,7]naphthyridine | CH...)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072200(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 200nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50072209(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 200nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14769(6-[4-(difluoromethoxy)-3-methoxyphenyl]-2,3-dihydr...)
Affinity DataIC50: 210nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50072199(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Affinity DataIC50: 210nMAssay Description:Evaluated for the inhibition of [3H]rolipram binding to membrane-bound PDE4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072194(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-butyl-6...)
Affinity DataIC50: 300nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 310nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085141(Trifluoro-methanesulfonic acid 8-(3-nitro-phenyl)-...)
Affinity DataIC50: 310nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072209(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Affinity DataIC50: 340nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085147(8-(3-Nitro-phenyl)-6-o-tolyl-[1,7]naphthyridine | ...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085143(Trifluoro-methanesulfonic acid 8-(3-cyano-phenyl)-...)
Affinity DataIC50: 420nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50072204(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethylsu...)
Affinity DataIC50: 440nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50085145(Trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)...)
Affinity DataIC50: 460nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50085137(6-Furan-2-yl-8-(3-nitro-phenyl)-[1,7]naphthyridine...)
Affinity DataIC50: 510nMAssay Description:Inhibitory activity against Phosphodiesterase 4B (PDE4B) from rat source expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50212893(CHEMBL298529)
Affinity DataIC50: 580nMAssay Description:Inhibition of [3H]rolipram binding to rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2018
Entry Details

LigandPNGBDBM50072205(4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-cyclopropy...)
Affinity DataIC50: 600nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072206(4-(3,5-Bis-cyclopropylmethoxy-phenyl)-6,7-dimethox...)
Affinity DataIC50: 650nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072212(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-q...)
Affinity DataIC50: 660nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 740nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50218550(CHEMBL327581)
Affinity DataIC50: 900nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50218544(CHEMBL88527)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50146545(2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of Phosphodiesterase 4 from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50218418(CHEMBL90189)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
LigandPNGBDBM50072198(4-(3,5-Diisopropoxy-phenyl)-6,7-dimethoxy-2-methyl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50072203(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-6-methoxy...)
Affinity DataIC50: 1.30E+3nMAssay Description:Evaluated for its ability to inhibit PDE4B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50218534(CHEMBL314537)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50218416(CHEMBL316449)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50218419(CHEMBL91952)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
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