Compile Data Set for Download or QSAR
Report error Found 10543 of affinity data for UniProtKB/TrEMBL: P0DTD1
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataEC50:  530nMAssay Description:In vitro inhibition of viral main protease inhibitors against SARS-CoV-2. (A and B) Vero E6 cells were treated with a series concentration of indicat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataEC50:  720nMAssay Description:In vitro inhibition of viral main protease inhibitors against SARS-CoV-2. (A and B) Vero E6 cells were treated with a series concentration of indicat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM31524(Naphthalene and Benzamide Derivative, 25 | 5-amino...)
Affinity DataEC50:  2.76E+4nMAssay Description:Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM31523(Naphthalene and Benzamide Derivative, 24 | med.217...)
Affinity DataEC50:  2.10E+4nMAssay Description:Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM419124(3CLpro inhibitor 6c)
Affinity DataEC50:  250nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM419127(3CLpro inhibitor 6e)
Affinity DataEC50:  150nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM419129(3CLpro inhibitor 6h)
Affinity DataEC50:  900nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM419131(3CLpro inhibitor 6j | 3CLpro inhibitor 7j)
Affinity DataEC50:  800nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM429507(Favipiravir | med.21724, Compound 181)
Affinity DataAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM13934(CGP 73547 | CHEMBL1163 | methyl N-[(1S)-1-{[(2S,3S...)
Affinity DataAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50438912(CHEMBL1096283 | US9073941, 619 | Walrycin B | MAT-...)
Affinity DataEC50:  3.55E+3nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420305(Z-FA-FMK | Z-FA-FM)
Affinity DataEC50:  130nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420306(DA-3003-1)
Affinity DataEC50:  4.47E+3nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420309(MG-115)
Affinity DataEC50:  23nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420315(TBB)
Affinity DataEC50:  1.41E+4nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50168081(CHEMBL3799802 | MK 0893)
Affinity DataEC50:  3.16E+3nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420321(Penta-O-galloyl-beta-D-glucose hydrate)
Affinity DataEC50:  1.26E+4nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50240436(2-hydroxy-6-pentadecylbenzoic acid | 6-(pentadecen...)
Affinity DataEC50:  3.98E+3nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420325(Adomeglivant | Adomeg-livan)
Affinity DataEC50:  3.16E+3nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataEC50:  8.91E+3nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM19992(2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]meth...)
Affinity DataEC50:  3.55E+3nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50289149(GW305074X | US10570155, GW5074 | GW5074 | US113324...)
Affinity DataEC50:  1.12E+4nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM31712(SMR000058356 | MLS000028433 | cid_3598 | HEXACHLOR...)
Affinity DataEC50:  790nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataEC50:  1.12E+4nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420331(AMG-837)
Affinity DataEC50:  1.12E+4nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataEC50:  1.26E+4nMAssay Description:SARS-CoV-2 CPE assay was conducted at Southern Research Institute (Birmingham, AL) as described in previous reports30, 31. In brief, high ACE2 expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataEC50:  420nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420297(med.21724, Compound 62 | peptidomimetic aldehydes ...)
Affinity DataEC50:  330nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM420295(med.21724, Compound 67 | alpha-ketoamide inhibitor...)
Affinity DataEC50:  4.50E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM429476(med.21724, Compound 150)
Affinity DataEC50:  2.06E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataEC50:  4.67E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM419120(the N3 Compound | cmdc.202100576, 8d(N3) | acs.jme...)
Affinity DataEC50:  1.68E+4nMAssay Description:To further substantiate the enzymatic inhibition results in vitro, we evaluated whether these compounds could prevent viral replication in cell-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM178090(5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)nap...)
Affinity DataEC50:  4.67E+3nMAssay Description:To further substantiate the enzymatic inhibition results in vitro, we evaluated whether these compounds could prevent viral replication in cell-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM429505(Remdesivir | med.21724, Compound 178 | US202400347...)
Affinity DataEC50:  770nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataEC50:  1.10E+5nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM429507(Favipiravir | med.21724, Compound 181)
Affinity DataEC50:  6.19E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM429508(med.21724, Compound 182)
Affinity DataEC50:  154nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM442744(Tolperisone)
Affinity DataEC50:  1.92E+4nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM442750(Isofloxythepin)
Affinity DataEC50:  4.80E+3nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM442751(Triglycidyl isocyanurate)
Affinity DataEC50:  3.00E+4nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50084655([(S)-1-((S)-1-Formyl-pentylcarbamoyl)-3-methyl-but...)
Affinity DataEC50: <1.56E+3nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataEC50:  3.82E+4nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-etho...)
Affinity DataEC50:  1.25E+3nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50083351(4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phen...)
Affinity DataEC50:  3.93E+4nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM442799(RS102859)
Affinity DataEC50:  1.98E+4nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM24654(pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...)
Affinity DataEC50:  2.52E+4nMAssay Description:Briefly, Vero E6 cells (ATCC CRL-1586) seeded at 3.5 × 104 cells/well in 96-well plates were inoculated with 50 μ l of serial tenfold dilutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataEC50:  120nMAssay Description:anti-cytopathic effect in a Vero-E6 cell line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM448272(MI-09)
Affinity DataEC50:  860nMAssay Description:The differential scanning fluorimetry (DSF) assay was carried out on a CFX96 real-time PCR Detection System (Bio-Rad). All the experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM448297(MI-12)
Affinity DataEC50:  530nMAssay Description:The differential scanning fluorimetry (DSF) assay was carried out on a CFX96 real-time PCR Detection System (Bio-Rad). All the experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shanghai Institute of Materia Medica

LigandPNGBDBM448299(MI-14)
Affinity DataEC50:  660nMAssay Description:The differential scanning fluorimetry (DSF) assay was carried out on a CFX96 real-time PCR Detection System (Bio-Rad). All the experiments were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
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