Compile Data Set for Download or QSAR
Report error Found 635 of affinity data for UniProtKB/TrEMBL: P06730
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50018919(CHEMBL254578)
Affinity DataKd:  8.74E+6nMAssay Description:Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50044268(CHEMBL3310215)
Affinity DataKd:  5.01E+6nMAssay Description:Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50044269(CHEMBL3310347)
Affinity DataKd:  3.66E+7nMAssay Description:Binding affinity to human full length recombinant GST-tagged eIF4E expressed in Escherichia coli BL21(DE3) by intrinsic tryptophan fluorescence quenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to purified elF4EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50249977(CHEMBL1234304)
Affinity DataKd:  800nMAssay Description:Binding affinity to eIF4E (unknown origin) by fluorescence titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451144(US10676499, Example 1)
Affinity DataKd:  300nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451146(US10676499, Example 18)
Affinity DataKd:  160nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451147(US10676499, Example 26)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451148(US10676499, Example 29)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451149(US10676499, Example 32)
Affinity DataKd:  30nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451150(US10676499, Example 33)
Affinity DataKd:  220nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451151(US10676499, Example 40)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451152(US10676499, Example 41)
Affinity DataKd:  20nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451153(US10676499, Example 42)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451154(US10676499, Example 43)
Affinity DataKd:  580nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451155(US10676499, Example 49)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451156(US10676499, Example 53)
Affinity DataKd:  6.00E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451157(US10676499, Example 54)
Affinity DataKd:  6.00E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451158(US10676499, Example 55)
Affinity DataKd:  110nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451159(US10676499, Example 57)
Affinity DataKd:  6.50E+3nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM451160(US10676499, Example 58)
Affinity DataKd:  410nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525087(CHEMBL4577429)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  21nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525089(CHEMBL4464315)
Affinity DataKd:  48nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525090(CHEMBL4558213)
Affinity DataKd:  30nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525091(CHEMBL4447089)
Affinity DataKd:  5.20nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525089(CHEMBL4464315)
Affinity DataKd:  0.0460nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525092(CHEMBL4444144)
Affinity DataKd:  123nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  0.0160nMAssay Description:Binding affinity to N-terminal 10His-tagged m7GDP-bound recombinant human eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKon:  0.0110M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50565475(CHEMBL4777401)
Affinity DataKon:  0.00420M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataKon:  0.00690M-1s-1Assay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by surface ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataKd:  17nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50565475(CHEMBL4777401)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50154375(Tribavirin | cid_37542 | Ribavirin | Adenosine rec...)
Affinity DataKd:  8.40E+3nMAssay Description:Binding affinity to eIF4E (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50607960(CHEMBL5289039)
Affinity DataKd:  2.50E+4nMAssay Description:Binding affinity to EIF4E (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50613700(CHEMBL1234303 | CHEBI:50226)
Affinity DataKd:  370nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50613701(CHEMBL1232939 | CHEBI:17825)
Affinity DataKd:  3.90E+3nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50613702(CHEMBL5282449)
Affinity DataKd:  5.65E+4nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50613703(CHEMBL5286550)
Affinity DataKd:  1.33E+5nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50613704(CHEMBL5283082)
Affinity DataKd:  5.78E+4nMAssay Description:Inhibition of m7GDP fluorescent probe binding to recombinant eIF4E (unknown origin) assessed as dissociation constant by fluorescence polarization as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Ser 209 phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50597686(CHEMBL5183975)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 6nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50597684(CHEMBL5203720)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50597685(CHEMBL5181488)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50386777(CHEMBL2046918)
Affinity DataIC50: 16nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50597682(CHEMBL5206647)
Affinity DataIC50: 16nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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