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TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92482(CDE-008 | US9120744, CDE-008)
Affinity DataKd:  23nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92487(CDE-031 | US9120744, CDE-031)
Affinity DataKd:  31nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92483(CDE-034 | US9120744, CDE-034)
Affinity DataKd:  67nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92484(CDE-056 | US9120744, CDE-056)
Affinity DataKd:  51nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92485(CDE-066 | US9120744, CDE-066)
Affinity DataKd:  3.10nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92486(CDE-082 | US9120744, CDE-082)
Affinity DataKd:  5.30nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92482(CDE-008 | US9120744, CDE-008)
Affinity DataKd:  23nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92487(CDE-031 | US9120744, CDE-031)
Affinity DataKd:  31nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92483(CDE-034 | US9120744, CDE-034)
Affinity DataKd:  67nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92484(CDE-056 | US9120744, CDE-056)
Affinity DataKd:  51nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92485(CDE-066 | US9120744, CDE-066)
Affinity DataKd:  3.10nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92486(CDE-082 | US9120744, CDE-082)
Affinity DataKd:  5.30nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50149275([{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol...)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to human immobilized PAI1 by surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92479(Tannic Acid, A | Tannic acid)
Affinity DataIC50: 7nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM175527(US9120744, CDE-003)
Affinity DataIC50: 10nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM175526(US9120744, CDE-002)
Affinity DataIC50: 10nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM175528(US9120744, CDE-004)
Affinity DataIC50: 10nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM175525(US9120744, CDE-001 (or 073))
Affinity DataIC50: 10nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92485(CDE-066 | US9120744, CDE-066)
Affinity DataIC50: 10nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50132862(4-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...)
Affinity DataIC50: 10nMAssay Description:Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50132855(1-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...)
Affinity DataIC50: 10nMAssay Description:Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM264615(US9718760, C182)
Affinity DataIC50: 33nMpH: 7.4 T: 2°CAssay Description:To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

LigandPNGBDBM264650(US9718760, C204)
Affinity DataIC50: 35nMpH: 7.4 T: 2°CAssay Description:To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50127745((E)-3-[3-(4-Chloro-phenoxy)-5,6-bis-(4-phenylsulfa...)
Affinity DataIC50: 39nMAssay Description:Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM175546(US9120744, CDE-061)
Affinity DataIC50: 50nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM175544(US9120744, CDE-058)
Affinity DataIC50: 50nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

LigandPNGBDBM264630(US9718760, C198)
Affinity DataIC50: 51nMpH: 7.4 T: 2°CAssay Description:To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM175558(US9120744, CDE-075)
Affinity DataIC50: 70nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM175548(US9120744, CDE-059)
Affinity DataIC50: 90nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataIC50: 91nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50127733((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-phenoxy-be...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50127735((E)-3-[3-(4-Chloro-phenoxy)-5,6-bis-(4-phenoxy-ben...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50132856(3-Hydroxy-4-[(4-{[2-((1R,2S,5R)-2-isopropyl-5-meth...)
Affinity DataIC50: 100nMAssay Description:Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50132853(3-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...)
Affinity DataIC50: 100nMAssay Description:Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM264611(US9718760, C188)
Affinity DataIC50: 120nMpH: 7.4 T: 2°CAssay Description:To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50127743((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-...)
Affinity DataIC50: 130nMAssay Description:Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50127732((E)-3-[3-(4-Chloro-phenoxy)-5,6-bis-(4'-methoxy-bi...)
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM264602(US9718760, C197)
Affinity DataIC50: 173nMpH: 7.4 T: 2°CAssay Description:To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

LigandPNGBDBM264616(US9718760, C183)
Affinity DataIC50: 180nMpH: 7.4 T: 2°CAssay Description:To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50111316(8-[4-(3,6-Dioxo-5-{4-[(thiophene-2-carbonyl)-amino...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1 (PAI-1) evaluated by chromogenic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50104502(8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-am...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity of compound against Plasminogen activator inhibitor-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50127742((E)-3-[5,6-Bis-(biphenyl-3-ylmethoxy)-3-(4-chloro-...)
Affinity DataIC50: 220nMAssay Description:Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50127726((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(3-fluoro-...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM264613(US9718760, C157)
Affinity DataIC50: 250nMpH: 7.4 T: 2°CAssay Description:To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50104502(8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-am...)
Affinity DataIC50: 260nMAssay Description:Tissue plasminogen activator generation in plasmin was evaluated by measuring the ability to inhibit Plasminogen activator inhibitor-1 through fibrin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50127730((E)-3-[5,6-Bis-(4-benzyl-benzyloxy)-3-(4-chloro-ph...)
Affinity DataIC50: 270nMAssay Description:Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92487(CDE-031 | US9120744, CDE-031)
Affinity DataIC50: 280nMpH: 7.8 T: 2°CAssay Description:To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50310309(N-(3,4-dihydroxyphenylsulfonyl)-N-hexyl-3,4-dihydr...)
Affinity DataIC50: 284nMAssay Description:Inhibition of human recombinant PAI1 assessed as rate of AMC release after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM264609(US9718760, C163)
Affinity DataIC50: 288nMpH: 7.4 T: 2°CAssay Description:To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50111273(6-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2-dihydr...)
Affinity DataIC50: 290nMAssay Description:Inhibitory activity against human plasminogen activator inhibitor-1 (PAI-1) evaluated by complex assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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