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TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123247((S)-3-{[5-(3-Guanidino-phenyl)-thiophene-2-carbony...)
Affinity DataIC50: 0.000920nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123246((S)-2-Benzenesulfonylamino-3-{[5-(4-guanidino-phen...)
Affinity DataIC50: 0.00130nMAssay Description:Inhibition of fibrinogen binding to integrin alphaIIb-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123251((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...)
Affinity DataIC50: 0.00580nMAssay Description:Inhibition of fibrinogen binding to integrin alphaIIb-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104592((S)-3-{[3-(2-Piperidin-4-yl-ethyl)-5,6,7,8-tetrahy...)
Affinity DataIC50: 0.0160nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50078440((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataKd:  0.0230nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50346317((S)-3-(3-chloro-4-(4-(1,4,5,6-tetrahydropyrimidin-...)
Affinity DataIC50: 0.0230nMAssay Description:Antagonist activity at alpha2bbeta3 integrin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50078444((S)-2-(4-Chloro-benzenesulfonylamino)-3-{[5-(2-pip...)
Affinity DataKd:  0.0260nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104598(RWJ-53419 | 2-Benzyloxycarbonylamino-3-{[(R)-1-(3-...)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50372593(CHEMBL410050)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor high affinity state by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of [125I]echistatin binding to integrin alphaVbeta3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50191290(3-(5-(2-chloro-4,5-dimethoxybenzylidene)-3-methyl-...)
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [125I]echistatin from integrin alphaVbeta3 in human NCI-H1975 cells after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123248((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidinomethy...)
Affinity DataIC50: 0.0330nMAssay Description:Antagonist activity at alphavbeta3 integrin receptor (unknown origin) by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123251((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50121964(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50107412(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104602(2-Benzyloxycarbonylamino-3-{[3-(2-piperidin-4-yl-v...)
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50390490(CHEMBL2071603)
Affinity DataKi:  0.0430nMAssay Description:Displacement of [125I]-c(RGDyK) from human integrin alphavbeta3 after 16 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104595(2-Phenylmethanesulfonylamino-3-{[3-(2-piperidin-4-...)
Affinity DataIC50: 0.0430nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50098965(3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimeth...)
Affinity DataKi:  0.0460nMAssay Description:Affinity for purified activated GPIIb/IIIa fibrinogen receptor by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145527((S)-5-{4-[3-(5-Fluoro-1,4,5,6-tetrahydro-pyrimidin...)
Affinity DataIC50: 0.0550nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50091733((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataKd:  0.0560nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145533((S)-2-Benzyloxycarbonylamino-5-oxo-5-{4-[3-(4,5,6,...)
Affinity DataIC50: 0.0560nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104591((S)-3-{[3-((E)-2-Piperidin-4-yl-vinyl)-5,6,7,8-tet...)
Affinity DataIC50: 0.0570nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145528((S)-2-Benzyloxycarbonylamino-5-oxo-5-{4-[3-(1,4,5,...)
Affinity DataIC50: 0.0580nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataKd:  0.0600nMAssay Description:Dissociation constant of radiolabeled compound binding to alpha-v-beta-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104600((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104597((S)-3-{[3-((E)-2-Piperidin-4-yl-vinyl)-5,6,7,8-tet...)
Affinity DataIC50: 0.0610nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50145530((S)-2-Benzyloxycarbonylamino-5-{4-[3-(5-fluoro-1,4...)
Affinity DataIC50: 0.0630nMAssay Description:Inhibitory activity was determined against human vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104594(2-Benzyloxycarbonylamino-3-{[3-(2-piperidin-4-yl-e...)
Affinity DataIC50: 0.0680nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092512(2-Benzenesulfonylamino-3-{4-[2-(5,6,7,8-tetrahydro...)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50078437((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataKd:  0.0700nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092512(2-Benzenesulfonylamino-3-{4-[2-(5,6,7,8-tetrahydro...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50153027((S)-3-Pyrimidin-5-yl-9-(5,6,7,8-tetrahydro-[1,8]na...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50078437((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataKd:  0.0700nMAssay Description:Dissociation constant for alpha IIb beta-3 integrin rested plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067222([6-(4-Carbamimidoyl-benzoylamino)-chroman-3-yl]-ac...)
Affinity DataIC50: 0.0730nMAssay Description:Inhibition of Fibrinogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50372594(CHEMBL437072)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]echistatin from human integrin alpha-V-beta-3 receptor high affinity state by solid phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50153031((S)-3-(2-Methyl-pyrimidin-5-yl)-9-(5,6,7,8-tetrahy...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of integrin alphaVbeta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50078441((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[3,2-b]th...)
Affinity DataKd:  0.0800nMAssay Description:Displacement of L-762,745 from Fibrinogen Receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125I]nonpeptide ligand (compound 7) from purified human recombinant alphaV-beta3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092511(3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoylamino...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of Vitronectin receptor, integrin alphaV-beta3 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50092509((S)-3-{4-[2-(6-Amino-pyridin-2-yl)-ethyl]-benzoyla...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of binding to human Vitronectin receptor (integrin alphaV-beta3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50058239((S)-3-{[4-Oxo-5-(2-piperidin-4-yl-ethyl)-5,6,7,8-t...)
Affinity DataKd:  0.0800nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50392279(CHEMBL2153647)
Affinity DataIC50: 0.0820nMAssay Description:Displacement of [125I]echistatin from integrin alpha5beta3 after 3 hrs by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50329685(CHEMBL1269295)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of biotinylated vitronectin binding to human alphaVbeta3 integrin after 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50098971(3-({3-Benzyl-2-[(Z)-4-carbamimidoyl-benzoylimino]-...)
Affinity DataIC50: 0.0900nMAssay Description:Affinity for purified activated GPIIb/IIIa fibrinogen receptor in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50078440((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataKd:  0.0900nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50098965(3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimeth...)
Affinity DataIC50: 0.0900nMAssay Description:Affinity for purified activated GPIIb/IIIa fibrinogen receptor in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50078438((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[3,2-b]th...)
Affinity DataKd:  0.0920nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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