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TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294522(US10112895, Compound 14 | N-[(2-benzyloxyphenyl)me...)
Affinity DataEC50:  7.90E+3nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294507(US10112895, Compound 1 | 4-[[5-bromo-2-[(4- fluoro...)
Affinity DataEC50:  1.99E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294508(US10112895, Compound 2 | 5-[(2- benzyloxyphenyl)me...)
Affinity DataEC50:  1.00E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
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TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50431843(CHEMBL2347241 | US10112895, Compound 3)
Affinity DataEC50:  1.39E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294512(US10112895, Compound 4 | 5-[[2-[(4- chlorophenyl)m...)
Affinity DataEC50:  1.10E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294513(US10112895, Compound 5 | 5-[[2-[(2- chlorophenyl)m...)
Affinity DataEC50:  1.49E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294514(US10112895, Compound 6 | 5-[[2-[(4- fluorophenyl)m...)
Affinity DataEC50:  1.39E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294515(US10112895, Compound 7 | 5-[(2-benzyloxy-5-bromo- ...)
Affinity DataEC50:  1.10E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294516(US10112895, Compound 8 | 5-[[5-chloro-2-[(2- fluor...)
Affinity DataEC50:  1.10E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294517(US10112895, Compound 9 | 4-[[2-[(3- nitrophenyl)me...)
Affinity DataEC50:  1.33E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM33154(SMR000231540 | cid_833990 | MLS000704391 | 4-[(2-p...)
Affinity DataEC50:  3.56E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294519(US10112895, Compound 11 | 2-[[2-[(3- nitrophenyl)m...)
Affinity DataEC50:  1.77E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294520(US10112895, Compound 12 | 4-[(2- benzyloxyphenyl)m...)
Affinity DataEC50:  1.94E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM294521(US10112895, Compound 13 | N-[(2-benzyloxyphenyl)me...)
Affinity DataEC50:  1.44E+4nMpH: 7.5Assay Description:Processive DNA synthesis was assessed by two types of assays: the Rapid Plate Assay and the M13 assay. The Rapid Plate Assay was performed as previou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
Go to US Patent

TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM33154(SMR000231540 | cid_833990 | MLS000704391 | 4-[(2-p...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343395(10-(cyclohexylamino)-12-[(2-hydroxyethyl)amino]-15...)
Affinity DataIC50: 3.41E+4nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM80984(4-chloro-2-[(5-chloro-2-hydroxyphenyl)thio]phenol ...)
Affinity DataIC50: 3.85E+4nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343412(4-[5-(4-bromophenyl)-4-phenyl-1H-imidazol-2-yl]-2,...)
Affinity DataIC50: 9.12E+4nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343393(N-(9-(3,4-dimethoxyphenylamino)-5,6,7,8-tetrahydro...)
Affinity DataIC50: 1.06E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343399(N-[6-(benzylamino)-1,3-dimethyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.32E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343400((4-tert-butyl-6-{2-methyl-5H,6H-pyrazolo[1,5-c]qui...)
Affinity DataIC50: 1.38E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343396(ethyl 4-(4-(dimethylamino)phenylamino)benzo[h]quin...)
Affinity DataIC50: 1.39E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343402(N-(4-(dimethylamino)phenyl)-2-(4-(furan-2-yl)-6-(t...)
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343388(7-((2-fluorophenyl)(4-methylpyridin-2-ylamino)meth...)
Affinity DataIC50: 1.57E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343403(4-methoxy-N-(1-(2-(4-methoxyphenoxy)ethyl)-1H-benz...)
Affinity DataIC50: 1.69E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343411(N-(2-methoxy-5-methylphenyl)-4-methyl-N-(2-(4-meth...)
Affinity DataIC50: 1.75E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343391(2-(4-chlorophenyl)-3-hydroxy-6-methyl-4H-chromen-4...)
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343387(6-chloro-N-(4-fluorophenyl)-2-(pyridin-2-yl)imidaz...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343410(7-(4-chlorobenzyl)-8-((4-(4-methoxyphenyl)piperazi...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343389(6-(2-(4-fluorophenylamino)-4-(4-(pyrrolidin-1-ylsu...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343390(4-methoxy-N-((1-(2-(p-tolyloxy)ethyl)-1H-benzo[d]i...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343392(4-(6-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343394(methyl 2-(2-(4-fluorophenyl)-8-methyl-4H-benzo[b]i...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343397(N2,N4-bis(2,4-dimethoxyphenyl)-6-morpholino-1,3,5-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343398(5-bromo-2-(5-(o-tolylamino)imidazo[2,1-b]thiazol-6...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343404(4-bromo-2-(3-(3,4-dimethoxyphenylamino)imidazo[1,2...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343405(6-(9-chloro-4-(4-fluorophenyl)-5H-chromeno[4,3-b]p...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343406(2-(2,4-dimethoxyphenylamino)-N-(3-(4-(2-fluorophen...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343407(2-(3-(3,4-dimethoxystyryl)-1-phenyl-1H-1,2,4-triaz...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343408(2-cyclohexyl-3-oxo-N-(3,4,5-trimethoxyphenyl)isoin...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343409(1-(2-(3,4-dimethoxyphenylamino)allyl)-3-(4-ethylbe...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetUracil-DNA glycosylase(VACV)
University of Pennsylvania

US Patent
LigandPNGBDBM50343401((4R)-4-(2-chlorophenyl)-8-ethoxy-3a,4,5,9b-tetrahy...)
Affinity DataIC50: 2.21E+5nMAssay Description:Inhibition of Vaccinia virus WR strain processivity factor D4 interaction with A20 protein assessed as inhibition of E9 DNA polymerase-mediated DIG-d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed