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Report error Found 1251 of affinity data for UniProtKB/TrEMBL: P00735
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM21740(2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,4...)
Affinity DatapH: 8.5 T: 2°CAssay Description:The enzyme reaction was initiated by adding fluorescence peptide substrate to reaction mixture containing enzyme and test compounds. The enzyme activ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50391540(CHEMBL2147469)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of bovine thrombin using Bz-Phe-Val-Arg-pNA as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50391541(CHEMBL2147467)
Affinity DataEC50:  4.90E+3nMAssay Description:Inhibition of bovine thrombin using Bz-Phe-Val-Arg-pNA as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by fluori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 8.90nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029498(1N-[2-{2-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50: 9.60nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029510(1N-[2-{2-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50: 13nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50269544(tellimagrandin II | CHEMBL510512)
Affinity DataIC50: 14nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029506(tert-butyloxy carbonyl-D-ethylphenylglycine-Pro-Ar...)
Affinity DataIC50: 16nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029515(tert-butyloxy carbonyl-D-Phe-azetidine-2-carboxyla...)
Affinity DataIC50: 18nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029500((S)-1-((S)-1,2,3,4-Tetrahydro-isoquinoline-3-carbo...)
Affinity DataIC50: 19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029501(5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]...)
Affinity DataIC50: 19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029514((S)-1-((R)-2-Acetylamino-2-phenyl-propionyl)-azeti...)
Affinity DataIC50: 19nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50280654((S)-5-Guanidino-2-{[(S)-1-((S)-2-methylamino-2-phe...)
Affinity DataIC50: 20nMAssay Description:In vitro concentration of compound required to inhibit 50% of 6 nM thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029507({(R)-2-[2-((S)-1-Formyl-4-guanidino-butylcarbamoyl...)
Affinity DataIC50: 22nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50269547(5-desgalloylstachyurin | CHEMBL488110)
Affinity DataIC50: 26nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50280655(3-Isobutyryloxy-benzo[4,5]thieno[3,2-b]furan-2-car...)
Affinity DataIC50: 30nMAssay Description:In vitro concentration of compound required to inhibit 50% of 6 nM thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50280655(3-Isobutyryloxy-benzo[4,5]thieno[3,2-b]furan-2-car...)
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine thrombin using Bz-Phe-Val-Arg-pNA as substrate by absorbance based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029511({(R)-1-Benzyl-2-[(S)-2-((S)-1-formyl-4-guanidino-b...)
Affinity DataIC50: 45nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50241052(1,2,3,4,6-pentakis-O-(3,4,5-trihydroxybenzoyl)-bet...)
Affinity DataIC50: 50nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50269546(casuariin | CHEMBL509562)
Affinity DataIC50: 59nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029502(1N-[2-[5-[4-amino(imino)methylamino-1-formyl-(1S)-...)
Affinity DataIC50: 64nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50269544(tellimagrandin II | CHEMBL510512)
Affinity DataIC50: 70nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029499(tert-butyloxy carbonyl-D-Phe-thiazolidine-4-carbox...)
Affinity DataIC50: 88nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50241052(1,2,3,4,6-pentakis-O-(3,4,5-trihydroxybenzoyl)-bet...)
Affinity DataIC50: 110nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM83506(SMR000147996 | MLS000556879 | (5Z)-5-[[9-methyl-4-...)
Affinity DataIC50: 148nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50242262(CHEMBL506204 | PEDUNCULAGIN)
Affinity DataIC50: 150nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of fibrinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404562(CHEMBL353809)
Affinity DataIC50: 150nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50242262(CHEMBL506204 | PEDUNCULAGIN)
Affinity DataIC50: 180nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50269547(5-desgalloylstachyurin | CHEMBL488110)
Affinity DataIC50: 190nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404544(CHEMBL355327)
Affinity DataIC50: 200nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50269546(casuariin | CHEMBL509562)
Affinity DataIC50: 280nMAssay Description:Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029512(tert-butyloxy carbonyl-D-Phe-DL-Pro(5,5-methyl)-Ar...)
Affinity DataIC50: 290nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404563(CHEMBL352975)
Affinity DataIC50: 300nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404567(CHEMBL168621)
Affinity DataIC50: 300nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM52848(SMR000437879 | cid_2002858 | MLS000333673 | [(2Z)-...)
Affinity DataIC50: 468nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM39775(SMR000174254 | MLS000557712 | 5-[3-(4-Dimethylamin...)
Affinity DataIC50: 529nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM88892(N-(2-chlorophenyl)-2-[(2E)-2-[(2-morpholin-4-yl-4-...)
Affinity DataIC50: 564nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404623(CHEMBL168547)
Affinity DataIC50: 670nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029505(5N-[4-amino(imino)methylamino-1-formyl-1-methyl-(1...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404564(CHEMBL353701)
Affinity DataIC50: 1.00E+3nMAssay Description:Bovine thrombin concentration at which clotting time was prolonged 2x over the control.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50046896(2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of thrombin with benzoyl-Phe-Val-arginine- p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM60483((5Z)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene...)
Affinity DataIC50: 1.37E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50046887(2-(2-Acetylamino-3-phenyl-propionylamino)-4-methyl...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of thrombin with benzoyl-Phe-Val-arginine- p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50024617(N-acetylhirudin45-65)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of plasma fibrin clot formation by thrombin in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM88918(cid_9658313 | N-[(E)-1-(1-benzofuran-2-yl)ethylide...)
Affinity DataIC50: 1.62E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50029504({(S)-1-Benzyl-2-[(S)-2-((S)-1-formyl-4-guanidino-b...)
Affinity DataIC50: 1.70E+3nMAssay Description:In vitro Enzyme Inhibitory activity measured against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404506(CHEMBL355622)
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration at which the clotting time was prolonged by twice the control was determined using topical bovine thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404530(CHEMBL166995)
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration at which the clotting time was prolonged by twice the control was determined using topical bovine thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM50404531(CHEMBL166822)
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration at which the clotting time was prolonged by twice the control was determined using topical bovine thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Georgetown University Medical Center

LigandPNGBDBM83218(MLS000573812 | 1-[(Z)-3-indolylidenemethyl]-2-(4-n...)
Affinity DataIC50: 2.05E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
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