Compile Data Set for Download or QSAR
Report error Found 439 of affinity data for UniProtKB/TrEMBL: O95069
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM60939(I-NBP)
Affinity DataEC50:  60nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataEC50:  187nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataEC50:  232nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataEC50:  354nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50088383(CHEBI:2668 | Amlodipine | Norvasc)
Affinity DataEC50:  430nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50117922(CHEMBL45816 | Methoxy-acetic acid 2-(2-{[3-(1H-ben...)
Affinity DataEC50:  500nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50453799(Niguldipine)
Affinity DataEC50:  750nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM86722(CAS_53772-85-3 | NSC_17012 | Flupenthixol, Beta | ...)
Affinity DataEC50:  2.00E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50017702(cid_6365505 | 1-(bis(4-fluorophenyl)methyl)-4-cinn...)
Affinity DataEC50:  2.48E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50408507(Chlorpromazine sulfoxide | CHLOROPROMAZINE SULFOXI...)
Affinity DataEC50:  2.70E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50066430(CHEMBL28854 | 2-(4-Methyl-piperazin-1-yl)-5-(2,3,5...)
Affinity DataEC50:  4.00E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]pro...)
Affinity DataEC50:  4.70E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM85675(CHEMBL321585 | Anandamide + PMSF)
Affinity DataEC50:  5.10E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50053408(Haldol | Haldol Dec | Haloperidol Decanoate | R-13...)
Affinity DataEC50:  5.50E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50101817(CHEBI:7565 | Adalat | Adalat Cc | Afeditab Cr | BA...)
Affinity DataEC50:  8.18E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataEC50:  9.00E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM81875(Fluoxetine-R-(-))
Affinity DataEC50:  1.90E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM22871(13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azat...)
Affinity DataEC50:  1.97E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataEC50:  2.41E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM181128(US9138393, Diltiazem)
Affinity DataEC50:  2.48E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataEC50:  6.40E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50350790(Bupivacaine | BUPIVACAINE HYDROCHLORIDE | SAMPL3, ...)
Affinity DataEC50:  1.13E+5nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataEC50:  3.77E+5nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM82053(8-(2-Furyl)theophylline | US9138393, Theophylline ...)
Affinity DataEC50:  4.86E+5nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50027886(N-[(butylamino)carbonyl]-4-methylbenzenesulfonamid...)
Affinity DataEC50:  7.84E+5nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM10458(pyridin-4-amine | CHEMBL284348 | 4-Aminopyridine 1...)
Affinity DataEC50:  2.75E+6nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  9.70E+3nMAssay Description:Activation of TREK1 (unknown origin) expressed in HEK293 cells assessed as increase in current density relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50180656(CHEMBL3818503)
Affinity DataEC50:  3.60E+4nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50180657(CHEMBL3819108)
Affinity DataEC50:  1.25E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50180658(CHEMBL3818800)
Affinity DataEC50:  2.13E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50180659(CHEMBL3818672)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of human TREK1 expressed in CHO cells assessed as increase in channel currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataEC50:  1.00E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in whole cell currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM30705(SMR000058231 | CHEMBL744 | cid_5070 | MLS000069369...)
Affinity DataEC50:  1.39E+5nMAssay Description:Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in whole cell currents at +50 mV relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50514764(CHEMBL4552751)
Affinity DataEC50:  1.84E+4nMAssay Description:Activation of recombinant human TREK1 G275C mutant expressed in HEK293T cells assessed as increase in K+ current amplitude in presence of MTSET by wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50514764(CHEMBL4552751)
Affinity DataEC50:  1.28E+4nMAssay Description:Activation of recombinant human TREK1 expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clamp electrophys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50514764(CHEMBL4552751)
Affinity DataEC50:  7.57E+3nMAssay Description:Activation of recombinant human TREK1 T156A mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50514764(CHEMBL4552751)
Affinity DataEC50:  7.98E+3nMAssay Description:Activation of recombinant human TREK1 I293A mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50514764(CHEMBL4552751)
Affinity DataEC50:  1.52E+4nMAssay Description:Activation of recombinant human TREK1 G275C mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50514764(CHEMBL4552751)
Affinity DataEC50:  2.24E+4nMAssay Description:Activation of recombinant human TREK1 F149A mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50514764(CHEMBL4552751)
Affinity DataEC50:  3.91E+3nMAssay Description:Activation of recombinant human TREK1 W290A mutant expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50546012(CHEMBL4761929)
Affinity DataEC50:  1.31E+4nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50197060(CHEMBL1417584)
Affinity DataEC50:  5.20E+3nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50545998(CHEMBL4745050)
Affinity DataEC50:  1.28E+4nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50545999(CHEMBL4778307)
Affinity DataEC50:  9.50E+3nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50546000(CHEMBL4780579)
Affinity DataEC50:  4.40E+3nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50546001(CHEMBL4776102)
Affinity DataEC50:  3.80E+3nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50546002(CHEMBL4747631)
Affinity DataEC50:  4.30E+3nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50546003(CHEMBL4759642)
Affinity DataEC50:  5.90E+3nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50546004(CHEMBL4759521)
Affinity DataEC50:  6.10E+3nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50546005(CHEMBL4758530)
Affinity DataEC50:  1.65E+4nMAssay Description:Activation of human TREK1 by thallium flux mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
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