Compile Data Set for Download or QSAR
Report error Found 41 of affinity data for UniProtKB/TrEMBL: O35186
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138858([(S)-1-(4-Phenyl-1H-pyrazol-3-ylaminooxalyl)-penty...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138869([(S)-1-(4-Methyl-1H-pyrazol-3-ylaminooxalyl)-penty...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138866([(S)-1-(1-Methyl-1H-pyrazol-3-ylaminooxalyl)-penty...)
Affinity DataIC50: 11nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138879([(S)-1-(5-Phenyl-1H-pyrazol-3-ylaminooxalyl)-penty...)
Affinity DataIC50: 12nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223929(7-(2,2-Dimethyl-propyl)-6-(3-methyl-2,4-dioxo-1,3,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138868([(S)-1-(1H-Pyrazol-3-ylaminooxalyl)-pentyl]-carbam...)
Affinity DataIC50: 13nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138842([(S)-1-(4-Bromo-1H-pyrazol-3-ylaminooxalyl)-pentyl...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against rat cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223934(7-(2,2-dimethyl-propyl)-6-(2,4-dioxo-8-propyl-1,3,...)
Affinity DataIC50: 27nMAssay Description:Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223913(7-(2,2-dimethyl-propyl)-6-(1,3-dioxo-2,8-diaza-spi...)
Affinity DataIC50: 30nMAssay Description:Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244510(7-(2,2-dimethylpropyl)-6-[(5-methoxy-2-oxospiro[in...)
Affinity DataIC50: 44nMAssay Description:Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50318880((S)-2-(4-(2-(1-(biphenyl-3-ylamino)cyclohexanecarb...)
Affinity DataIC50: 58nMAssay Description:Inhibition of rat cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50244460(7-(2,2-dimethylpropyl)-6-[(2,4-dioxo-1,3,8-triazas...)
Affinity DataIC50: 76nMAssay Description:Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50223919(7-(2,2-dimethylpropyl)-6-{5-fluoro-2-oxo-1,2-dihyd...)
Affinity DataIC50: 78nMAssay Description:Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50177494({(S)-1-[(morpholine-4-carbonyl)-hydrazonomethyl]-p...)
Affinity DataIC50: 130nMAssay Description:Inhibition of rat cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138867([(S)-1-(2-Pyridin-4-yl-2H-pyrazol-3-ylaminooxalyl)...)
Affinity DataIC50: 470nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138854([(S)-1-(2-Phenyl-2H-pyrazol-3-ylaminooxalyl)-penty...)
Affinity DataIC50: 790nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138849([(S)-1-(2-Isopropyl-2H-pyrazol-3-ylaminooxalyl)-pe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138865([(S)-1-(2-Cyclobutyl-2H-pyrazol-3-ylaminooxalyl)-p...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138847([(S)-1-(2-Cyclopentyl-2H-pyrazol-3-ylaminooxalyl)-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138850([(S)-1-(2-Pyridin-2-yl-2H-pyrazol-3-ylaminooxalyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138877([(S)-1-(2-Cyclohexyl-2H-pyrazol-3-ylaminooxalyl)-p...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138855([(S)-1-(2-Ethyl-2H-pyrazol-3-ylaminooxalyl)-pentyl...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138844({(S)-1-[2-(3,3-Dimethyl-butyl)-2H-pyrazol-3-ylamin...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138851([(S)-1-(2-Methyl-2H-pyrazol-3-ylaminooxalyl)-penty...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138848([(S)-1-(2-Cyclopropylmethyl-2H-pyrazol-3-ylaminoox...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50138872([(S)-1-(2-Isobutyl-2H-pyrazol-3-ylaminooxalyl)-pen...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of cysteine protease cathepsin K of ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM25141(7-[2-(4,4-difluorocyclohexyl)ethyl]-6-[4-(4-acetyl...)
Affinity DataIC50: 1.00E+4nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM25135(7-(2-cyclohexylethyl)-6-[4-(4-acetylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM25134(CHEMBL481170 | 7-(2-cyclohexylethyl)-6-[4-(4-acety...)
Affinity DataIC50: 1.00E+4nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167288((1S)-1-benzylpropyl 2-cyano-2-methylhydrazinecarbo...)
Affinity DataKi:  0.0720nMAssay Description:Inhibition constant against rat cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  4.80nMAssay Description:Inhibitory activity against Rat cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  8nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19769(CHEMBL286364 | (2S)-2-(1-benzofuran-2-ylformamido)...)
Affinity DataKi:  60nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19769(CHEMBL286364 | (2S)-2-(1-benzofuran-2-ylformamido)...)
Affinity DataKi:  60nMAssay Description:Inhibitory activity against Rat cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19775((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  73nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19780((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  430nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19777((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  660nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19779((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  680nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19781((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  790nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19776((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi: >1.00E+3nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19774((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi: >1.00E+3nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed