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TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50239186(CHEBI:50182 | 1,1-Bis(3''-Indolyl)Methane | 3,3''-...)
Affinity DataKd:  5.30E+5nMAssay Description:Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L mutant after 24 hrs by equilibrium dia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50239186(CHEBI:50182 | 1,1-Bis(3''-Indolyl)Methane | 3,3''-...)
Affinity DataKd:  7.60E+5nMAssay Description:Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L, K430N mutant after 24 hrs by equilibr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246595(Camptothecin (CPT))
Affinity DataIC50: 2.80E+3nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617104(CHEMBL5395724)
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246595(Camptothecin (CPT))
Affinity DataIC50: 4.20E+3nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617108(CHEMBL5407977)
Affinity DataIC50: 5.25E+3nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617096(CHEMBL5427724)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617104(CHEMBL5395724)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of recombinant Top1 in Leishmania donovani Ag83 whole cell extract assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617094(CHEMBL5431960)
Affinity DataIC50: 6.75E+3nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617097(CHEMBL5413499)
Affinity DataIC50: 7.25E+3nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617095(CHEMBL5434027)
Affinity DataIC50: 7.25E+3nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617103(CHEMBL5422628)
Affinity DataIC50: 8.52E+3nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617104(CHEMBL5395724)
Affinity DataIC50: 8.75E+3nMAssay Description:Inhibition of recombinant Top1 in Antimony resistant Leishmania donovani BHU575 whole cell extract assessed as relaxation of supercoiled pBluescript ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617090(CHEMBL5396760)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617107(CHEMBL5397183)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617106(CHEMBL5393978)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617105(CHEMBL5405905)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617089(CHEMBL5434098)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617102(CHEMBL5428175)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617101(CHEMBL5394200)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617100(CHEMBL5405408)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617099(CHEMBL5430320)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617098(CHEMBL5427528)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617088(CHEMBL5423477)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617093(CHEMBL5394451)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617092(CHEMBL5403760)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617091(CHEMBL5431403)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Leishmania donovani Top1 assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by agarose gel electrophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617108(CHEMBL5407977)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant Top1 in Leishmania donovani Ag83 whole cell extract assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617096(CHEMBL5427724)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of recombinant Top1 in Leishmania donovani Ag83 whole cell extract assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617094(CHEMBL5431960)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of recombinant Top1 in Leishmania donovani Ag83 whole cell extract assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246594(Bi-lawsone analog, 3d)
Affinity DataIC50: 1.30E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246593(Bi-lawsone analog, 3c)
Affinity DataIC50: 1.40E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617097(CHEMBL5413499)
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of recombinant Top1 in Leishmania donovani Ag83 whole cell extract assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50617095(CHEMBL5434027)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of recombinant Top1 in Leishmania donovani Ag83 whole cell extract assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246591(Bi-lawsone analog, 3a)
Affinity DataIC50: 1.60E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246592(Bi-lawsone analog, 3b)
Affinity DataIC50: 1.70E+4nMpH: 7.5Assay Description:In the preincubation assay, CPT concentrations were 50 and 100 μM, whereas various concentrations of compounds were 25, 50 and 100 μM. LdTOP1LS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I(Leishmania donovani)
India Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of recombinant Top1 in Leishmania donovani Ag83 whole cell extract assessed as relaxation of supercoiled pBluescript SK(+) DNA measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246592(Bi-lawsone analog, 3b)
Affinity DataIC50: 3.75E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246591(Bi-lawsone analog, 3a)
Affinity DataIC50: 5.10E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246594(Bi-lawsone analog, 3d)
Affinity DataIC50: 7.00E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed
TargetDNA topoisomerase I/type IB small subunit(Leishmania donovani)
Karunya University

LigandPNGBDBM246593(Bi-lawsone analog, 3c)
Affinity DataIC50: 7.40E+4nMpH: 7.5Assay Description:In simultaneous relaxation assay, CPT concentrations were 50 and 100 μM, whereas concentration of compounds were 50, 100 and 200 μM. Relaxation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2017
Entry Details Article
PubMed