Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) for PDB: 9WQM
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258140BDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  56nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258140BDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  141nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258140BDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  141nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258140BDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  202nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258140BDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  245nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in wild type T-Rex 293 cells assessed as increase in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258140BDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  246nMAssay Description:Positive allosteric modulation of human mGlu1 receptor expressed in wild type T-Rex 293 cells assessed as increase in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]quisqualate from mGluR1 receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258140BDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  275nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258140BDBM50258140(N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-c...)
Affinity DataEC50:  277nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  570nMAssay Description:Displacement of [3H]Quisqualate from human mGluR1A receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.05E+3nMAssay Description:Effect of compound on Metabotropic glutamate receptor 1 expressed in HEK 293 cells was determined by measuring IP production relative to glutamateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.59E+3nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity in rat at Metabotropic glutamate receptor 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  7.30E+3nMAssay Description:Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  7.30E+3nMAssay Description:Activity at rat recombinant mGluR1 expressed in CHO cells assessed as intracellular calcium concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  9.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  9.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1a in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  9.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1a in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  1.00E+4nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2011
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.30E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1c in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.39E+4nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.90E+4nMAssay Description:Agonistic activity at mGlu1-alpha receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  5.60E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1b in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17657BDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.56E+5nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1b in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)